Application of the collision of aptamer Pt nanoparticles in the brain of rats for the detection of unlabeled amperometrics of proteins

Proteins are the building blocks and core protagonists of the cell, involved at the molecular level in all processes of the nervous system, such as signaling, learning, and memory

Single-particle collision is an emerging, powerful, and sensitive collision detection technique, but its application in the detection of biological macromolecules (such as proteins) in complex biological environments remains challenging when analyzing

On March 19, 2019, the research group of Zhang Yue et al.

Method: Schematic diagram

Results: The electrochemical oxidation of hydrazine at CFME is a slow process that does not reach a steady state

To obtain high sensitivity and a suitable potential, they chose hydrazine as an indicator of electrochemical collision measurements

They studied collision events

The aptamer/PtNPs conjugate is highly selective in its response to PDGF, noting that exposed PtNPs can adsorb proteins, which also inhibits signaling

Conclusion: In summary, the study proposes a simple electrochemical collision method for the sensitive and selective detection

-END-

For more information, please contact us for inquiries

Phone : +86-0731-84428665

Contact: Manager Wu +86-180 7516 6076