Artificial pancreas is coming

Artificial pancreas is coming

New device provides more effective treatment for patients with type 1 diabetes

Artificial pancreas to the artificial pancreas to thenew equipment with type 1 diabetes to provide more effective treatment of new patients with type 1 diabetes equipment to provide more effective treatment for new equipment to provide more effective treatment for patients with type 1 diabetes

A convection-enhanced encapsulation device enhances the nutrient transport of transplanted cells, thereby improving survival and glucose-responsive insulin secretion
.

Photo Credit: Brigham and Women's Hospital/Randal McKenzie

More than 40 million people worldwide suffer from type 1 diabetes, which is an autoimmune disease in which the beta cells that produce insulin in the pancreas are destroyed by the immune system
.

At present, there are several new and emerging methods for the treatment of type 1 diabetes, including macro-encapsulation devices (MED)-compartments used to contain and protect insulin-secreting cells

However, these medical devices have limitations, and it has always been a challenge to extend such devices to the human body
.

Researchers from Brigham and Women’s Hospital, Harvard University and the University of Massachusetts Medical School have collaborated to design a convection-enhanced MED (ceMED), which can continuously bathe cells in the nutrients they need and increase cell load Ability to improve cell survival, glucose sensitivity and timely secretion of insulin

"Due to recent developments, we are getting closer and closer to having infinite sources of beta-like cells that can respond to glucose by secreting insulin, but the next challenge is how to combine these cells in a minimally invasive, long-lived, and most functional way.
Cells are introduced into the body
.

" said Jeff Karp, the corresponding author of the paper, "Our device has proven the increase in cell viability and minimal delay after transplantation

ceMED is designed to provide convective nutrition to the encapsulated cells through a continuous flow of liquid, allowing multi-layered cells to grow and survive
.

The team’s prototype machine has two key parts-an equilibrium chamber (EqC) to collect nutrients from the surrounding environment, and a cell chamber (CC) to accommodate protected cells

The researchers said that compared with traditional insulin pumps, the device has many advantages, allowing cells to secrete insulin on demand and quickly stop secreting insulin when blood sugar levels drop

Related paper information: https://doi.