AS: Professor Wang Weilin of Zhejiang University School of Medicine, Second Hospital, designed new nanodrugs for cascading chemical/chemical dynamics cancer treatment.

Innovation point (1) through in situ binding AuNP on MOF surface to realize cascade reaction, AuNP nano enzyme catalyzes glucose decomposition to produce H2O2, and TCPP (FE) released by MOF in tumor cells catalyzes H2O2 to produce hydroxyl radicals, which can realize high-efficiency chemokinetic therapy.(2) by modifying C12 and peg with AuNP on MOF surface, the catalytic effect of nanodrugs in blood / normal tissues can be shielded, and the toxicity can be reduced; the stability of nanodrugs can be improved, long circulation can be realized, and the drug delivery effect can be improved.(3) the response of MOF to porous structure and phosphate radical was used to realize the loading and responsive release of camptothecin (CPT) The team of Professor Wang Weilin and Professor Yan Sheng of the Second Affiliated Hospital of Zhejiang University and Professor Mao Zhengwei of the Department of polymer of Zhejiang University take the metal organic framework (MOF) of in-situ combination of ultra-small gold nanoparticles (AuNP) as nanodrugs through the design of material structure to achieve the synergy of chemotherapy / chemodynamic therapy It can effectively inhibit the growth of tumor.for a long time, traditional chemotherapy plays a key role in cancer treatment, but single chemotherapy has poor efficacy, side effects and easy to produce drug resistance.combined with emerging multimodal therapy, the synergistic effect of 1 + 1 & gt; 2 is an effective way to improve the anti-tumor effect of chemotherapy.recently, Professor Wang Weilin, Professor Yan Sheng and Professor Mao Zhengwei from the Department of polymer, Zhejiang University, reported a breakthrough on this issue in the journal advanced science (2018if: 15.804) in the first district. For the first time, ultra-small gold nanoparticles (AU) with the function of glucose oxidase were prepared In situ binding of NPs to metal organic frameworks (MOFs) for cascade chemotherapy / chemodynamic therapy.in this system, MOF nanoparticles (femof NPs) were constructed from TCPP (FE) and zirconium clusters. Camptothecin (CPT), a hydrophobic chemotherapeutic drug, was loaded into the porous structure.ultra small Au NPs were formed on MOF surface in situ, which was modified by c12sh and peg-sh to improve the stability of the nanoparticles. The catalytic activity of Au NPs was blocked to avoid damage to normal tissues while realizing long cycle.the nanodrug has a long circulation time in vivo, and has good high permeability and retention (EPR), so it can be passively targeted to tumor areas.after entering tumor cells, zirconium in nano drugs coordinated with phosphate in cells, which made the nanoparticles degrade rapidly, releasing CPT, TCPP (FE) and AuNP on their surface, so as to realize the synergy of chemotherapy and chemokinetic therapy.this study innovatively combined the catalytic ability of Au NPs nanoenzyme with Fenton reaction catalyzed by TCPP (FE) to realize cascade chemokinetic therapy.TCPP (FE) can catalyze the concentration of H2O2 in tumor cells higher than that in normal cells to produce highly active hydroxyl radicals, and then kill tumor cells in combination with chemotherapy drugs.however, ultra-small Au NPs have the catalytic ability of glucose like oxidase, which can catalyze the decomposition of intracellular glucose to produce H2O2, which not only consumes energy in tumor cells, but also provides more fuel for Fenton reaction.finally, under the cascade effect of AuNPs glucose oxidase and Fenton reaction, the high-efficiency chemokine therapy was realized, which cooperated with chemotherapy to improve the effect of cancer treatment.the nano drug has been proved to have obvious anti-tumor effect in vitro and in vivo experiments, and compared with chemotherapy alone, the systemic toxicity is greatly reduced.this research is in the leading position in the world. The use of ultra-small Au NPs to catalyze intracellular glucose oxidation effectively solves the problem of insufficient endogenous H2O2 in tumor cells faced by chemokinetic therapy.combined with Fenton reaction of TCPP (FE) to realize cascade chemokinetic therapy.it provides a new idea for the design of advanced nano drugs for chemotherapy / chemodynamic synergistic therapy.Biography of the corresponding author: Wang Weilin, Zhejiang special expert, honorary academician of Hong Kong Academy of surgery, Honorary Professor of Hong Kong University, vice president of China Hospital Association, member of Standing Committee of external science branch of Chinese Medical Association, director of Zhejiang Provincial Key Laboratory for precise diagnosis and treatment of hepatobiliary and pancreatic tumors, director of Zhejiang Provincial Center for diagnosis and treatment of liver cancer, director of Zhejiang Provincial Center for diagnosis and treatment of liver, gallbladder and pancreas diseases He is director of Cardiology, director of Zhejiang Engineering Laboratory of medical artificial intelligence, director of Surgical Research Institute of Zhejiang University, and special doctor of Zhejiang University.Mao Zhengwei, Department of polymer science and engineering, Zhejiang University.National "excellent youth" and provincial "outstanding youth".Yan Sheng, deputy director of hepatobiliary pancreatic surgery, Second Affiliated Hospital of Zhejiang University, director of pancreas transplantation center.innovative talents of Zhejiang health high level talent training program.resume of the first author: Dr. Ding Yuan, deputy director of Key Laboratory for precise diagnosis and treatment of hepatobiliary pancreatic tumors in Zhejiang Province, vice chairman and Secretary General of the Youth Committee of the accelerated rehabilitation surgery branch of Zhejiang Medical Association, Secretary General of the Youth Committee of the surgery branch of the Chinese Medical Association, and the accelerated rehabilitation surgery specialty of the National Health Commission Member and Secretary General of organ transplantation group of family Committee.doctoral students Xu Hao, Xu Chang and Tong Zongrui are the co first authors of this paper. The results were published in advanced science (DOI: 10.1002 / advs. 202001060).original link: