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The importance of multicellular spheres (MCSs) models as a complement to two-dimensional cell culture models and animal models has been recognized
.
Although this model has been widely used in oncology drug screening, recent studies have also shown that traditional methods to generate multispheroids by forced aggregation through anti-cell adhesion still have limitations, high necrosis/ Apoptotic rates and limited cell line applicability limit its application
.
Studies have shown that this is mainly due to the lack of physical stimulation from the extracellular matrix
.
Self-organization is a basic feature of embryonic development and tissue formation.
Since this process is greatly affected by the cellular microenvironment, the biophysical factors of the matrix can regulate the formation of multicellular spheres and the formation of multicellular spheres through self-organization.
omics features, thereby providing insights for exploiting this concept to develop 3D tumor cell models with high tumor tissue similarity and for evaluating novel drugs and therapeutic technologies in vitro
.
Recently, Associate Professor Hu Ke and Dr.
Yu Tingting of Nanjing Medical University proposed a method to construct a tumor multicellular sphere model based on a hydrogel with tunable elastic modulus, stress relaxation and cell adhesion properties as a culture substrate.
Previous experience in a series of applications of hydrogels as three-dimensional cell culture substrates for signaling pathway regulation studies and in vitro evaluation of novel tumor treatment strategies
.
This method has several advantages: 1.
Provides a hydrogel matrix with appropriate mechanical properties and cell adhesion ability, which can maintain cell viability during cell culture; 2.
Cells spontaneously self-organize on hydrogels Form multicellular spheroids, which is a more in vivo approach; 3.
The multicellular structures (spheres/monolayers) formed on hydrogels can be tuned by changing the mechanical properties of the material, which is useful for studying multicellular spheroid formation Mechanisms and cellular self-organization mechanisms provide a new platform
.
Based on this platform and the previous cooperation with Shenzhen Xiwangxin Materials Technology Co.
, Ltd.
, it was reported for the first time that the combined therapeutic effect of far-infrared and clinical drugs produced by graphene devices has obvious synergistic therapeutic effect on colorectal tumor multicellular spheres.
Its subsequent clinical application laid the foundation
.
WILEY Paper Information: Self-Organization Formation of Multicellular Spheroids Mediated by Mechanically Tunable Hydrogel Platform: Towards Revealing the Synergy of Chemo- and Noninvasive Photothermal Therapy against Colon Microtumor Yi Zhang, Zhao-bin Guo, Yu-min Nie, Guan-ping Feng, Man -jiao Deng, Yi-min Hu, Hui-jie Zhang, Yin-yi Zhao, Yi-wei Feng, Ting-ting Yu*, Ke Hu*Macromolecular Bioscience DOI: 10.
1002/mabi.
202100498 Click "Read the original text" in the lower left corner to view The original text of the paper
.
Introduction to Macromolecular Bioscience "Macromolecular Bioscience" involves the fields of regenerative medicine, tissue engineering, drug delivery and biomedicine.
It is an advanced journal in the fields of polymer, material science and biomedicine
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information to follow us and share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
.
Although this model has been widely used in oncology drug screening, recent studies have also shown that traditional methods to generate multispheroids by forced aggregation through anti-cell adhesion still have limitations, high necrosis/ Apoptotic rates and limited cell line applicability limit its application
.
Studies have shown that this is mainly due to the lack of physical stimulation from the extracellular matrix
.
Self-organization is a basic feature of embryonic development and tissue formation.
Since this process is greatly affected by the cellular microenvironment, the biophysical factors of the matrix can regulate the formation of multicellular spheres and the formation of multicellular spheres through self-organization.
omics features, thereby providing insights for exploiting this concept to develop 3D tumor cell models with high tumor tissue similarity and for evaluating novel drugs and therapeutic technologies in vitro
.
Recently, Associate Professor Hu Ke and Dr.
Yu Tingting of Nanjing Medical University proposed a method to construct a tumor multicellular sphere model based on a hydrogel with tunable elastic modulus, stress relaxation and cell adhesion properties as a culture substrate.
Previous experience in a series of applications of hydrogels as three-dimensional cell culture substrates for signaling pathway regulation studies and in vitro evaluation of novel tumor treatment strategies
.
This method has several advantages: 1.
Provides a hydrogel matrix with appropriate mechanical properties and cell adhesion ability, which can maintain cell viability during cell culture; 2.
Cells spontaneously self-organize on hydrogels Form multicellular spheroids, which is a more in vivo approach; 3.
The multicellular structures (spheres/monolayers) formed on hydrogels can be tuned by changing the mechanical properties of the material, which is useful for studying multicellular spheroid formation Mechanisms and cellular self-organization mechanisms provide a new platform
.
Based on this platform and the previous cooperation with Shenzhen Xiwangxin Materials Technology Co.
, Ltd.
, it was reported for the first time that the combined therapeutic effect of far-infrared and clinical drugs produced by graphene devices has obvious synergistic therapeutic effect on colorectal tumor multicellular spheres.
Its subsequent clinical application laid the foundation
.
WILEY Paper Information: Self-Organization Formation of Multicellular Spheroids Mediated by Mechanically Tunable Hydrogel Platform: Towards Revealing the Synergy of Chemo- and Noninvasive Photothermal Therapy against Colon Microtumor Yi Zhang, Zhao-bin Guo, Yu-min Nie, Guan-ping Feng, Man -jiao Deng, Yi-min Hu, Hui-jie Zhang, Yin-yi Zhao, Yi-wei Feng, Ting-ting Yu*, Ke Hu*Macromolecular Bioscience DOI: 10.
1002/mabi.
202100498 Click "Read the original text" in the lower left corner to view The original text of the paper
.
Introduction to Macromolecular Bioscience "Macromolecular Bioscience" involves the fields of regenerative medicine, tissue engineering, drug delivery and biomedicine.
It is an advanced journal in the fields of polymer, material science and biomedicine
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information to follow us and share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
