Astaxanthin can inhibit the metastasis of colon cancer cells

Recently, researchers from Jiaquan University in South Korea published a research paper in scientific reports, which was approved by high-throughput drugs (http:// Astaxanthin was screened and identified as a new cancer cell metastasis inhibitor The results showed that astaxanthin could inhibit the transcription of Myc, increase the expression of mir-29a-3p and mir-200a, then inhibit the expression of MMP2 and ZEB1, and inhibit the EMT process The researchers found that astaxanthin can inhibit the formation of pseudopods in colon cancer cells and inhibit the metastasis of colon cancer cells The researchers found that astaxanthin inhibited MMP2 activity by up regulating mir-29a-3p, and astaxanthin inhibited ZEB1 expression by enhancing mir-200a The inhibition of MMP2 and ZEB1 resulted in the inhibition of EMT In addition, astaxanthin can negatively regulate the expression of Myc, and the decrease of Myc can restore the expression of mir-29a-3p and mir-200a The researchers conducted animal experiments in vivo, and the results (http:// showed that astaxanthin can effectively inhibit the metastasis activity of colon cancer cells in mouse models in vivo.