Atomic Force Microscopy of Lipid Domains in Supported Model Membranes
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Last Update: 2020-12-21
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Source: Internet
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Author: User
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Atomic force microscopy (AFM) has been a significant tool in the characterization of lipid domains in model membranes. WithAFM, one can image the structure of membranes in a natural fluid environment with a lateral resolution that approaches 1 nmand vertical resolution of 0.1 nm. The AFM technique is discussed, with a special emphasis on imaging soft, compliant memranesthat are supported on solid substrates such as glass or mica. In typical model membranes, lipid domains are formed by phaseseparation in multicomponent lipid mixtures and are observed by nm-level height differences owing to lipid packing. A generalprocedure for creating supported lipid bilayers through vesicle fusion is discussed.
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