[attention] DNA technology and artificial intelligence from "black technology" will shorten the research and development cycle of new drugs at 2018 innovation drug discovery Summit Forum

"The target of disease is like a lock New drug development is to find the key to unlock the lock." On October 19, at the 2018 International Summit Forum on the frontier and practice of innovative drug discovery, Li Tianquan, co-founder and President of data business department of yaozhi.com (Chongqing Kangzhou big data Co., Ltd.), shared the current situation and trend of global new drug research and development Li Tianquan, co-founder of pharmaceutical intelligence network and President of data business division, is understood that at present, the average R & D time of a drug, from the beginning of design to the drug market, generally takes 15 years, and the R & D cost is more than $1 billion If the failure cost is included, it may be close to $4 billion Li Tianquan said that the traditional research and development of new drugs is to find out the "key" of compounds one by one, and then "unlock" them one at a time The one that can be opened is the compound needed by new drugs If you find the "key" manually, you can only try one million at most, which is not necessarily found, so the research and development cycle of new drugs is long DNA coding compound library technology can shorten the period of new drug discovery, which is one of the most advanced technologies in the field of new drug discovery It can improve the efficiency of drug discovery of major disease difficult targets Generally speaking, the key group can be "unlocked" to screen more compounds and shorten the time In order to further explore the technology of DNA coding compound library, the 8th International Forum on DNA coding compound library technology was also held at the same time "This is the first time that the forum has been held in China, indicating the international position of China, especially Chengdu, in this field." Li Jin, chairman of Chengdu pilot drug development Co., Ltd., said that there are only three companies in the world that can carry out large-scale new drug R & D cooperation based on DNA coding compound library technology, one of which is Chengdu pilot At present, China's only and world leading DNA coding small molecule compound library is located in Chengdu At present, the first innovative drug independently developed by Chengdu pilot company has passed the examination and approval The drug is about to enter the phase I clinical stage for multiple myeloma, which marks the birth of another innovative drug in China from Chengdu In addition to DNA coding compound library technology, the meeting also discussed the application of big data, artificial intelligence and other new technologies in new drug research and development Li Tianquan said that at present, drug intelligence network has used artificial intelligence to carry out drug aided design, input compounds into the database, then combine drugs according to Literature and other data, find the closest compounds through virtual synthesis experiments, and conduct artificial verification, "this is also the trend of new drug research and development in the future." Coincidentally, Jingtai technology is also trying to use new technology to shorten the time of new drug development Lai Lipeng, co-founder of the company and head of research and development of big data and artificial intelligence, said that the company is cutting into drug research through quantum mechanics + cloud computing "We are generating similar molecular structures through a non-stop running machine, and can quickly screen the properties of all aspects of the sub components effectively." For example, Lai Lipeng uses carbon elements The composition mode of diamond and graphite is carbon, but their properties are different Diamond is very valuable, while graphite is not There are the same problems in drugs For example, the absorption effect of different structures of aspirin in the body is different, so drug companies are concerned about how to find a good structure "In the past, many experiments can only be carried out after you have obtained molecular entities With this virtual screening technology, you can make a prediction before solubility and toxicity When the prediction reaches a certain accuracy, it can greatly help pharmaceutical companies save experimental time and cost."