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Neuropathic pain is one of the most common chronic pain, which is a direct consequence of somatosensory system diseases or diseases.
More and more evidences show that neuroinflammation and the immune system play an important role in the occurrence and development of neuropathic pain.
immunity
In addition, autophagy is an evolutionarily conserved process that plays an important role in the regulation of immune inflammation and nervous system homeostasis.
Recently, researchers published an article in the Journal of Autophagy that in the maintenance of neuropathic pain, the impairment of autophagy flux mainly occurs in astrocytes .
Impaired autophagic flux mainly occurs in astrocytes.
After autophagy inhibition or activation, neuroinflammation and reactive oxygen species (ROS) levels increase or decrease, respectively.
Impaired autophagy is involved in the process of neuralgia
Impaired autophagy is involved in the process of neuralgiaImpairment of autophagy also reduces the protective effect of astrocytes on neurons against ROS stress , because the level of glutathione released by astrocytes decreases, which can be improved by activating the NFE2L2/NRF2 pathway.
The impairment of autophagy also reduces the protective effect of astrocytes on neurons against ROS stress.
Therefore, this study provides the basic mechanism by which autophagy participates in the regulation of neuropathic pain .
The combined activation of autophagy and NFE2L2 may be a new treatment for neuropathic pain The combined activation of autophagy and NFE2L2 may be a new treatment for neuropathic pain
Original source:
Original source:Jian Li et al.
Jian Li et al.
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