Autophagy: Cannabinin causes motor dysfunction by suppressing autophagy.

Currently, recreational and medical use of cannabis is increasing worldwide.
, however, cannabis use can cause adverse side effects, it is important to conduct innovative research aimed at understanding and possibly reducing the harm caused by cannabis.
existing studies of cultured nerve cells have shown that CNR1/CB1R (cannabinin-like subject 1) is the main molecular target of cannabis, through which cannabis can affect macrophages/autophagy.
, however, it is not known whether CNR1 controls autophagy in the brain in the body and, ultimately, what the functional consequences of the potential CNR1-autophagy connection may be.
, researchers recently published a paper in the journal Autophagy, which found that synth autophagy in mice is impaired by the main intoxicating ingredient of cannabis, THC.
autophagy activators (especially ripple temsirolimus and dlyhalose) can rescue THC-induced autophagy inhibition and motor disorders.
combination of various genetic strategies in the body also supports the idea that CNR1 molecules located on neurons belonging to the direct (syroid) pathway are necessary for the autophagy and motor damage activity of THC.
by identifying autophagy as a mechanism link between THC and motor performance, the findings could open up new ideas about how marijuana works in the brain.
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