Autophagy: Wang Wuyang's team from Xuzhou Medical University found that targeting lysosomal ion channels can treat pancreatic cancer

Autophagy is an evolutionarily conserved degradation process that helps eliminate unwanted proteins and damaged organelles, and provides necessary nutrients for cell survival, especially under various stress conditions.

Recently, researchers found that MCOLN1/TRPML1 is a pancreatic cancer , breast cancer ,Drug targets for carcinogenic autophagy in cancers such as gastric cancer , malignant melanoma and glioma.

In recent studies, researchers have shown that by increasing the expression of the MCOLN1 channel or using the MCOLN1 agonist ML-SA5 or MK6-83 to activate MCOLN1, the fusion between autophagosomes and lysosomes can be disrupted to prevent cell autonomy.

Activation of MCOLN1 can specifically regulate autophagy

On this basis, the researchers demonstrated that the influx of zinc from extracellular fluid can prevent autophagy through the same mechanism as lysosomal zinc, confirming the basic function of zinc as a participant in membrane trafficking.

Consistent with the in vitro results , administration of ML-SA5 in Patu 8988 t xenograft mice can effectively inhibit tumor growth and improve survival.

Original source:

Jiansong Qi et al.