B cells may play an important role in the immunotherapy of melanoma

Recently, researchers from the European Institute of bioinformatics of the European Molecular Biology Laboratory (EMBL) and the Vienna Medical University have found that B cells may play an important role in the immunotherapy of melanoma Recently, a study published in nature communications showed that B cells, like T cells, play a key role in triggering melanoma related inflammation B cell is a kind of white blood cell, which can produce antibodies and several important messenger molecules In cases of melanoma, the researchers found that B cells act almost like a satellite navigation system, signaling T cells to tumors by secreting this unique messenger molecule The researchers found that when B cells in melanoma patients decreased, the number of T cells and other immune cells in the tumor also decreased significantly In the experiment, the researchers found that a special B cell subtype seems to be responsible for guiding T cells and other immune cells into the tumor The researchers also found that melanoma cells seem to force B cells to develop this unique B cell subtype This specific B-cell subtype also increases the activation of T cells by immunotherapy at present, and the more the number of this B-cell subtype before tumor treatment, indicates the better response of patients to follow-up immunotherapy.