Bacteria wear "camouflage suits" for long-term accurate imaging of tumors

Bacteria is a common microorganism, because of its unique advantages, such as gene editing, rapid reproduction and lesions, especially tumor sites are easy to enrich the characteristics, in bioimaging, disease diagnosis and treatment has attracted wide attentionHowever, using bacteria to do the above work, how to ensure safety while improving the effectiveness of the body is still a huge challengeAlthough a range of engineered bacteria have entered Phase I/II clinical trials, the dose-dependent toxic side effects and lower therapeutic effects of bacteria have become insurmountable stumbling blocks in the path of bacterial treatment of tumorsto this end, Liu's team took off the cell membrane coat of blood cells and wore them to bacteria, proposing a simple strategy of "bacterial stealth"This method can not only reduce the immunogenicity and inflammatory reaction produced by bacteria without affecting bacterial activity, but also reduce the elimination of the body's immune system and thus improve the enrichment of bacteria in the tumor site because the red blood cell membrane has a natural anti-swallowing abilitytake the probiotic Nissle 1917 as an example, wearing a "camouflage coat" can significantly increase the amount of the bacteria in the body, thus providing more time and probability to enter tumor tissue with the help of anaerobic tendencies, 42 times more than undisguised bacteriaAccurate imaging of tumors for up to 12 days with a single injection is achieved by bacterial expression of fluorolastase enzymesUnlike small molecules or nanoimaging reagents, Nissle 1917 can selectively enrich the tumor site (-99.9% bacteria) and can be found in tumor tissue for long periods of time by splitting and proliferating, resulting in accurate and long-cycle imaging of tumor storts.