Balanced regulatory factor Bap180/Baf180 for the natural immune response of the intestine.

The paper Bap180/Baf180 is required to maintain homeostasis of the intestinal innate immune response in Drosophila and mice, published april 18 in the latest issue of nature Microbiology.
intestinal tissue is the body's largest mucosal immune site, in which natural immunity as the first line of defense is essential to maintain the micro-environmental balance of intestinal immunity.
not only to remove invasive pathogens quickly and forcefully, but also to maintain symblotic bacteria.
and overactive natural immune response can cause disorders in the gut micro-environment and damage to the intestinal cortectal tissue, leading to localized enteritis (Inflammatory Bowel Disease, IBD) and even systemic diseases such as asthma and type 1 diabetes.
understanding and mastering the balance of the natural immune response in the gut is essential for human health.
fruit flies have been widely used in the study of natural immunity, especially intestinal mucous membrane immunity, with the help of natural immune signaling paths and intestinal structures that are highly similar to those of higher animals.
Based on this, the fruit fly research team of the Key Laboratory of Infection and Immunization of the Chinese Academy of Sciences used fruit flies to build a mature model of pathogenic infection, and used a large-scale genetic screening system to find that the Bap180 factor has a new function of regulating the natural immune balance of the intestine.
In this study, it was found that the Bap180 factor itself responded to the natural immune path path path iD in the intestines (the same as the NF-kB pathrain from higher animals) and restricted the over-activeness of the IMD natural immune path path at the transcription level with negative feedback, while inhibiting inflammatory intestinal inflammatory storms and intestinal cortective tissue damage mediated by the inflammatory factor Eiger (also derived from the higher animal TNF).
in the intestines further confirmed that Baf180 (also derived from the fruit fly Bap180) had the same conservative mechanism in higher animals.
not only that, the study also showed that the Bap180 factor not only inhibits inflammatory storms caused by acute infections of pathogens, but also has an important balancing effect on the accumulation of chronic inflammation of the intestine triggered by symblobacter.
In this way, the team found an important regulatory factor that monitors the natural immune balance of the body's intestines, Bap180/Baf180, and analyzed it as a key node to link natural immune pathlines and inflammatory reactions, providing an important theoretical basis for future diagnosis of enteritis or the development of drug targets.
Institute of Biophysics for the first unit of the research work, the Chinese Academy of Sciences Infection and Immunization Key Laboratory Assistant Researcher He Xiaomeng and Associate Researcher Zhai Wei as the co-first author of the paper, the Chinese Academy of Sciences Infection and Immunology Key Laboratory Researcher Pan Lei and the Chinese Academy of Sciences Shanghai Pasteur Institute Researcher Tang Hong as the co-author of the paper.
the study was jointly funded by the Chinese Academy of Sciences Youth Promotion Association and the National Natural Science Foundation of China.
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