BBRC: Low-intensity exercise may help prevent schizophrenia

At present, schizophrenia is one of the most serious diseases affecting human health, its symptoms and signs are complex and diverse, involving cognitive, thinking, emotional and behavioral barriers and mental incooration.
the cause of schizophrenia is not known, is an unforced disease, however, the implementation of effective preventive measures for people at high risk, reducing risk factors, may help to reduce the incidence.
more and more evidence that environmental factors play an important role in the development of schizophrenia, but multivariable environmental factors make it difficult to separate beneficial mechanisms.
to solve this problem, researchers recently designed a new model of exercise that would allow mice to run on a treadmill at a fixed speed to assess the effects of low-intensity exercise on preventing schizophrenia.
The researchers randomly divided the mice into control groups and phenyl hydrochloric acid cyclolyceride (PCP) test groups, examined the behavior and neurological function of mice exposed to PCP during development, and then performed four weeks of low-intensity exercise during puberty and tested them to see if they exhibited abnormal behavior and associated neurological abnormalities.
results that improved ERK1/2 phosphorication levels in prenatal PCP-treated mouse brain tissue were surprising, and that mild movement during development can prevent schizophrenia by masking or improving genetically occurring neurodevelopmental abnormalities.
important for the underlying neuropathology of schizophrenia, especially considering that low-intensity exercise can restore changes in nerve signals associated with expected behavioral abnormalities.
, low-intensity exercise can prevent abnormal behavior, suggesting that exercise may directly contribute to the prevention of schizophrenia.
planning for people at high risk of schizophrenia may prevent the development of schizophrenia and may help prevent it.
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