Behavioural Brain Research: Regulation of glutamate functional connections by typical antipsychotics: based on immediate early post-synaptic gene network analysis

Schizophrenia is a devastating mental illness with a high lifetime prevalence, including hallucinations, delusions, escape, and cognitive impairment.

Twenty-six male rats with an average weight of 250 grams were used in our study.

The Pearson correlation coefficients of the HAL group and the VEH group were used to calculate all possible pairwise correlations among the 33 roi.

The comparison between non-standardized data shows that solutes and haloperidol are only significantly different on the dorsolateral and ventrolateral of caudate putamen, and on the dorsal medial (p=0.

The observed changes in network parameters indicate that the functional organization of the brain network has undergone multimodal adaptation after acute haloperidol administration.

Annarita Barone, Simona Signoriello, Gianmarco Latte, Licia Vellucci, Giuseppe Giordano, Camilla Avagliano, Elisabetta F Modulation of glutamatergic functional connectivity by a prototypical antipsychotic: Translational inference from a postsynaptic density immediate-early gene-based network analysis , Behavioural Brain Research,