Beyond the new direction of β-amyloid target therapy Alzheimer's disease research

CompilationAspirin

For the past 20 years, research into Alzheimer's drugs has focused on targeting the beta-viscous amyloid plaques that are a hallmark of Alzheimer's disease

Biogen's Aduhelm received Fast Track approval from the U.

However, many researchers believe that drugs that target amyloid alone are not effective in preventing Alzheimer's disease

target tau

Many scientists believe that tau may pose a greater threat than amyloid because tau aggregation is directly linked to cognitive decline

Although the medical community still lacks in-depth understanding of the role of tau in Alzheimer's pathology, this has not dampened the enthusiasm of researchers to develop new therapeutics targeting tau

Unfortunately, efforts to target tau protein still have a long way to go, and no drug has yet successfully submitted a new drug marketing application to the FDA

Sound and light stimulate brain waves

Scientists believe the treatment is completely non-invasive and could therefore truly transform the way Alzheimer's disease is treated

The team exposed the mice to lights and sounds to induce gamma waves in their brains to intensify and synchronize

In the next small-scale clinical test, the team used a portable device to generate 40-hertz acousto-optic pulses and asked patients to use the device for an hour a day

The results come from a study of 15 people

immune cell therapy

Immune cells are not only the brain's first line of defense against bacteria, but also absorb amyloid and a range of other toxic substances

Denali's drug DNL919, which was once highly anticipated, is an antibody transporter (ATV) specifically designed to activate TREM2

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