Bio Valley recommendation: January must-see heavyweight study Top10

In mice with antiphospholipid syndrome or lupus, 6-curcumics can block the release of neutral granulocyte extracellular trapping nets, which can be induced by autoantibodies produced by the disease.
researcher Dr Ramadan Ali said neutrogenic granulocyte extracellular trapping webs (NETs) come from white blood cells called neutrogenic granulocytes, which form a viscous cobweb-like structure when autoantibodies interact with the subjects on the surface of neutrogenic granulocytes.
these mesh structures play a key role in the pathological manifestations of lupus and antiphospholipid syndrome, which induce the formation of autoantibodies and promote blood clotting and damage effects.
: Scientists hope to use stem cell therapy to successfully correct the skull and brain function of mouse models of cranial suture early closure are expected to be transformed into doi:10.1016/j.cell.2020.11.037 in human clinical applications In a study published in the international journal Cell, scientists from the National Institutes of Health and others used stem cells to regenerate parts of the skull, promising to correct the skull shape of young mice with craniosynostosis and reverse their learning and memory impairments.
According to the CDC, one in every 2,500 newborns is affected by early cranial closure, and the only treatment currently is complex surgery within a year of birth, but skull defects usually recur later, and the results of this paper hope to help develop more effective and less invasive treatments for early cranial closure.
researcher Lillian Shum said the study was a crucial one, demonstrating structural regeneration and functional recovery mechanisms in the brains of animal models of early cranial slits; the results could be translated into potential therapies for early cranial closure in humans.
healthy babies are born with a "sutures" structure, an elastic tissue that fills the space between the skulls, which, in the first few years of life, promotes skull expansion as the brain grows rapidly; In the disease, one or more suture structures enter the bone prematurely, causing gaps between the skull plates to close and trigger abnormal growth of the skull;
Image Source: Chinese Academy of Sciences 6 JAMA Network Open: Chinese scientists have developed a new deep learning technique that promises to successfully predict hidden peritometrial metastasis in patients with stomach cancer! doi:10.1001/jamanetworkopen.2020.32269 Stomach cancer is a common gastrointestinal malignancies that often occur in most patients with advanced stomach cancer, which is considered an invasive cancer and often has poor prognosis.
patients with peritina metastasis for stomach cancer are generally not suitable for root-and-drug surgery;
a recent study published in the international journal JAMA Network Open entitled "Noninvasive Prediction of Occult Peritoneal Metastasis in Gas Cancertric Using Deep Learning" by scientists from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences and others Research has developed a deep learning technique to help predict hidden peritometrial metastasis in patients with stomach cancer, and in this article, researchers offer a new and non-invasive way to diagnose gastric cancer patients, with the results promising to help develop individualized surgical treatments for gastric cancer patients.
Cell: Heavy! Scientists have developed a new coloring technique to successfully map the brain! doi:10.1016/j.cell.2020.12.012 The human brain contains about 86 billion neuron cells, woven together by about 100 trillion synhapal connections;
, given the large number of neurons and their connections, researchers don't yet know how neurons work together to produce brain thoughts or behaviors.
, in a study published in the international journal Cell, scientists from Columbia University and others developed a coloring technique called NeuroPAL to identify every neuron in a nematode's brain; NeuroPAL, or neuronal polychromatic marker map, could help researchers conduct research in the beautiful recessive rod nematodes.
the coloring technique could use a genetic method to color neuron cells, helping scientists identify each neuron in an animal's nervous system and recording the entire active nervous system.
: People who eat foods rich in vitamin C and E may have a one-third lower risk of Parkinson's disease! Doi:10.1212/WNL.00000000011373 A recent study published in the international journal Newology found that researchers from abroad found that people who ate foods rich in vitamin C and vitamin E may have a reduced risk of Parkinson's disease by nearly a third.
foods rich in vitamin C include oranges, strawberries, broccoli and sprouted kale, and vitamin E-rich foods include spinach, kale, pumpkin and tree nuts such as peanuts and almonds.
so how effective are these two substances in preventing Parkinson's disease? The researchers say vitamins C and E are effective in suppressing the antioxidants that cause cell damage from Parkinson's disease, specifically by helping to ward off unstable molecules and oxidative stress, which can lead to the loss of brain chemicals that become dopamine, a major marker of Parkinson's disease.
researcher Essi Hantikainen said the protective effects of vitamins on Parkinson's disease may be limited to specific vitamins such as vitamins C and E, so eating foods rich in both vitamins may help prevent Parkinson's disease.
, the researchers also found high concentrations of vitamin C in the central nervous system, which plays a role in nerve protection.
9" Alzheimer's and Dementia: Watch out! Unhealthy eating patterns may reduce or even counteract the health effects of a healthy diet! Doi:10.1002/alz.12277 Healthy eating styles such as the Mediterranean diet often have a positive effect on the body's health, but the effects of adding an unhealthy diet to the body's health are not currently clear to researchers;