Biological manufacturing: Prospect and strategy

Bio manufacturing is a strategic emerging industry in the world It is estimated that industries with more than 40% of GDP can become the development space of bio manufacturing The world economic cooperation and Development Organization (OECD) forecasts that by 2030, 35% of chemicals and other industrial products will come from biological manufacturing China's biological manufacturing industry has entered the stage of industrialization and is forming industry Its field and scale are expanding, and it has formed a new growth point of national economy Among them, the scale of amino acid, vitamin, organic acid and other bulk fermentation products ranks first in the world, with an output value of more than 100 billion yuan; the production of ethylene glycol, butanol, ethylene and other biological methods has been realized; the production of bioplastics, biochemical fiber and other new materials has begun to take shape; pantothenic acid, acrylamide, nisin and other products occupy 50% - 70% of the world market However, compared with developed countries, there is still a certain gap In the future, we should start from the following aspects to develop the biological manufacturing industry First, we will increase government support for the bio manufacturing industry The lack of support from venture capital funds is a relatively prominent problem Relevant departments should promote the financing system for the development of biological industry and give full play to the joint investment system of finance, finance and securities, including the formulation of national plans for the development of biological manufacturing industry, overall planning and cooperative implementation, Establish a national engineering research center and engineering laboratory with cross field, high level and advanced facilities; support the establishment of demonstration or test plants; formulate favorable tax policies and production policies to support new bio based products; create a good investment environment and attract foreign and private capital Second, establish and improve the raw material supply and product system of biological manufacturing The rational development of biological manufacturing must rely on the sustainable development of non food crops, non edible oil crops and agricultural and forestry wastes The statistics and verification of biomass resources should be carried out in an all-round way to understand the quantity and distribution of biomass waste and agricultural resources suitable for China's development The feasibility study of Bioenergy Industry should be carried out according to the characteristics of China's regional resources and regional economy On this basis, the rational planning should be carried out according to local conditions, and the utilization of various raw materials and production systems of various products should be developed and utilized scientifically Site selection, transformation nearby, breakthrough of technical limitations, and organic connection of decentralized agricultural production with continuous and automated industrial production Third, we should develop the combination of biocatalysis and chemical catalysis Petrochemical industry has a history of more than 90 years, and its development mode will provide many valuable experiences for the biological manufacturing industry Conditionally combining the two production modes is one of the effective countermeasures to promote the development of China's bio manufacturing industry Biochemical industry has obvious and superior characteristics in biomass pretreatment technology, fermentation technology, deep processing technology of fermentation products and treatment technology of fermentation residue, and chemical catalysis has formed its own unique advantages in industrial catalysis technology and chemical technology after a hundred years of development and continuous improvement Fourth, guide the formation of bio manufacturing related industrial clusters China's bio manufacturing industry should build a new system of biomass processing and a new biocatalyst system, give full play to the high efficiency and selectivity of biocatalysis and biotransformation, and build a biomass cycle model based on biodiversity and large biological chain At the same time, the development of biological manufacturing industry can promote the rise of related industrial clusters Take PHA as an example First of all, it can be used as plastic, packaging materials, medical implant materials, which can be collected and processed into biodiesel after use Second, the monomer obtained after PHA degradation can be used as a drug to improve memory, promote brain cell regeneration, or as a feed additive All these industries are interconnected to form the whole industry chain Fifth, pay attention to the development of synthetic biology and other scientific issues and related technologies Strengthening the research on scientific issues and related technological innovation that have important influence and are likely to have significant changes, such as synthetic biology, will effectively improve the core competitiveness of China in the field of global bioeconomy in the future It is suggested to establish a synthetic biology research network in China and carry out interdisciplinary research in the light of relevant research organizations and international cooperation in this field Support a number of practical and guiding demonstration projects; establish a special policy coordination group for synthetic biology to study the application of synthetic biology in bioenergy, biomaterials and new drug development, social ethics and other important issues (from cibn)