Biometabolism molecule creatine can promote cancer metastasis

Recently, the researcher of the Key Laboratory of Separation Analytical Chemistry of the Chinese Academy of Sciences and the team of Researcher Pu Hailong, researcher of the Institute of Biophysics of the Chinese Academy of Sciences , and the team of Deputy Chief Physician Chen Gang of the Seventh Medical Center of the Chinese People's Liberation Army General Hospital, have discovered in vitro supplementation and in vivo anabolic molecule creatine.

Cancer metastasis is the main cause of death of cancer patients, and it is also the difficulty of cancer treatment.

Scientists further used clinical tissues and mouse models to study and found that the rate-limiting enzyme GATM for creatine synthesis is highly expressed in liver metastasis colon cancer tissues; inhibiting GATM expression or enzyme activity can significantly inhibit colon cancer metastasis and prolong tumor-bearing The survival time of the mouse.

Related paper information: org/10.