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The balance of metabolic energy is essential for the normal life activities of microbial cells and the synthesis of metabolites (microbial manufacturing)
.
However, due to the low efficiency of metabolic energy supply and excessive consumption of metabolic energy, the balance of metabolic energy is often disrupted in the microbial manufacturing process, which restricts the efficient synthesis and production of metabolites
.
Therefore, how to effectively maintain the balance of metabolic energy during the microbial manufacturing process to improve the efficiency of product synthesis is an important scientific and technical issue
.
Under normal circumstances, it is difficult for microbial cells themselves to compensate for their metabolic energy requirements under specific production conditions by regulating their intracellular metabolism
.
Therefore, designing and ensuring the balance of cell metabolic energy through biotechnology engineering will be an important strategy and means to improve cell growth and microbial production performance
.
The team of Professor Liu Gaoqiang from Central South University of Forestry and Technology and the team of Professor Liu Liming from Jiangnan University published the Metabolic Energy Balance in the top international journal "Biotechnology Advances" with the title of "Engineering Microbial Metabolic Energy Homeostasis for Improved Bioproduction" (Top, IF 14.
227) Review papers on microbial manufacturing
.
In the article, the author fully discussed the latest progress in metabolic energy balance engineering for improving microbial manufacturing, and proposed some strategies to improve the metabolic energy balance through bioengineering methods: (1) For autotrophic microorganisms, the ability to harvest metabolic energy should be strengthened , That is, through the design of metabolic energy balance engineering harvesting system in autotrophic microorganisms to enhance the harvest of metabolic energy, including maximizing the use of light energy in the light energy nutrition system, accelerating the electron transfer in the chemical energy nutrition system, and enhancing bioelectricity.
nutrition and other electronic acquisition system
.
Strategies for enhancing the ability of metabolic energy harvesting in autotrophic microorganisms (2) For heterotrophic microorganisms, the pathway of metabolic energy generation should be optimized and the supply of metabolic energy should be improved, including optimizing the extracellular microenvironment, improving the efficiency of internal self-metabolic energy supply, and engineering metabolism energy supply and other modules
.
Strategies to increase the supply of metabolic energy in heterotrophic microorganisms (3) Reduce metabolic energy consumption
.
Reduce the consumption of metabolic energy by reorganizing the metabolic pathways and physiological processes in the microbial cells, including the development and construction of metabolic energy-saving systems in the cells, and the reorganization of metabolic energy-consuming pathways
.
Strategies to reduce metabolic energy consumption in microbial cells Finally, the author also discussed the future challenges and application prospects in the field of metabolic energy balance engineering
.
This paper emphasizes the application potential of biotechnology in the engineering of microbial metabolic balance.
The relevant strategies proposed have important reference value in the field of engineering cell metabolic energy balance to improve the efficiency of microbial manufacturing
.
The two scientific research platforms of Central South University of Forestry and Technology are the first and second units respectively.
The 2019 Ph.
D student Tong Tian in microbiology is the first author, and his supervisor Professor Gaoqiang Liu is the corresponding author; the two scientific research platforms of Jiangnan University are the third respectively.
, 4 units, Professor Liu Liming is the corresponding author of the school
.
Original link: https:// Graphic source: Plant Microbiology Frontline Public Account Plant Biotechnology Pbj Exchange Group In order to more effectively help the majority of scientific researchers to obtain For related information, Plant Biotechnology Pbj has established a WeChat group, Plant Biotechnology Journal submissions and document-related questions, public account release content and public account submission questions will be concentrated in the group for answers, while encouraging academic exchanges and collision thinking within the group
.
In order to ensure a good discussion environment in the group, please add the editor WeChat first, scan the QR code to add, and then we will promptly invite you to join the group
.
Tips: When adding the editor WeChat and after joining the group, please be sure to note the school or unit + name.
Please indicate the PI at the end and we will invite you to join the PI group
.
.
However, due to the low efficiency of metabolic energy supply and excessive consumption of metabolic energy, the balance of metabolic energy is often disrupted in the microbial manufacturing process, which restricts the efficient synthesis and production of metabolites
.
Therefore, how to effectively maintain the balance of metabolic energy during the microbial manufacturing process to improve the efficiency of product synthesis is an important scientific and technical issue
.
Under normal circumstances, it is difficult for microbial cells themselves to compensate for their metabolic energy requirements under specific production conditions by regulating their intracellular metabolism
.
Therefore, designing and ensuring the balance of cell metabolic energy through biotechnology engineering will be an important strategy and means to improve cell growth and microbial production performance
.
The team of Professor Liu Gaoqiang from Central South University of Forestry and Technology and the team of Professor Liu Liming from Jiangnan University published the Metabolic Energy Balance in the top international journal "Biotechnology Advances" with the title of "Engineering Microbial Metabolic Energy Homeostasis for Improved Bioproduction" (Top, IF 14.
227) Review papers on microbial manufacturing
.
In the article, the author fully discussed the latest progress in metabolic energy balance engineering for improving microbial manufacturing, and proposed some strategies to improve the metabolic energy balance through bioengineering methods: (1) For autotrophic microorganisms, the ability to harvest metabolic energy should be strengthened , That is, through the design of metabolic energy balance engineering harvesting system in autotrophic microorganisms to enhance the harvest of metabolic energy, including maximizing the use of light energy in the light energy nutrition system, accelerating the electron transfer in the chemical energy nutrition system, and enhancing bioelectricity.
nutrition and other electronic acquisition system
.
Strategies for enhancing the ability of metabolic energy harvesting in autotrophic microorganisms (2) For heterotrophic microorganisms, the pathway of metabolic energy generation should be optimized and the supply of metabolic energy should be improved, including optimizing the extracellular microenvironment, improving the efficiency of internal self-metabolic energy supply, and engineering metabolism energy supply and other modules
.
Strategies to increase the supply of metabolic energy in heterotrophic microorganisms (3) Reduce metabolic energy consumption
.
Reduce the consumption of metabolic energy by reorganizing the metabolic pathways and physiological processes in the microbial cells, including the development and construction of metabolic energy-saving systems in the cells, and the reorganization of metabolic energy-consuming pathways
.
Strategies to reduce metabolic energy consumption in microbial cells Finally, the author also discussed the future challenges and application prospects in the field of metabolic energy balance engineering
.
This paper emphasizes the application potential of biotechnology in the engineering of microbial metabolic balance.
The relevant strategies proposed have important reference value in the field of engineering cell metabolic energy balance to improve the efficiency of microbial manufacturing
.
The two scientific research platforms of Central South University of Forestry and Technology are the first and second units respectively.
The 2019 Ph.
D student Tong Tian in microbiology is the first author, and his supervisor Professor Gaoqiang Liu is the corresponding author; the two scientific research platforms of Jiangnan University are the third respectively.
, 4 units, Professor Liu Liming is the corresponding author of the school
.
Original link: https:// Graphic source: Plant Microbiology Frontline Public Account Plant Biotechnology Pbj Exchange Group In order to more effectively help the majority of scientific researchers to obtain For related information, Plant Biotechnology Pbj has established a WeChat group, Plant Biotechnology Journal submissions and document-related questions, public account release content and public account submission questions will be concentrated in the group for answers, while encouraging academic exchanges and collision thinking within the group
.
In order to ensure a good discussion environment in the group, please add the editor WeChat first, scan the QR code to add, and then we will promptly invite you to join the group
.
Tips: When adding the editor WeChat and after joining the group, please be sure to note the school or unit + name.
Please indicate the PI at the end and we will invite you to join the PI group
.
