BJA: Drugs that reduce the risk of coughing caused by whole hemp trachea intubation

Background and objectivecough caused by a full linetrac intubation can have a negative outcome for patients, but it is not clear which drug is most effective in reducing the conditionIn this study, a systematic review and meta-analysis were carried out on randomized controlled trials to determine the relative efficacy of the drug in reducing sudden coughafters after general anesthesiaThe drugs studied benefited Docain (intravenous, subcutaneous injection, local or intratube use), right metoramidin, rifentanil and fentanylwe searched 8 different medical literature databases, conference summaries and related referencesAfter screening, the included citations are evaluated for bias and the data is extractedThe combined advantage ratio and 95% confidence interval for each study comparison were assessed comprehensivelyThe area under cumulative curve analysis (SUCRA) determines the effectiveness of each intervention that reduces sudden coughingSubgroup analysis included severe coughing, the number of tube extractions, anaesthetic maintenance patterns, and drug doseoutcomethis meta-analysis included 70 studies and 5,286 patientsThe drugs in all studies were more effective than not using drugs or placebos in reducing the amount of severe cough during the tube-pulling periodRight Mettami has the highest SUCRA rating, followed by Riffentani, Fentanyl and Lidocain (intratube, subcutaneous/local and venous pathways)Riffentini ranks highest in reducing severe coughingThe trachea were more likely to have extended tube extraction time than placebo, right metamine, fentanyl, and rifentaniconcluded all research drugs were better than placebo or no drug treatment in alleviating moderate to severe sudden cough, of which right-hand metomia was the most effective