Blood products analysis report

1 Definition and types of blood products Blood products: a general term for plasma protein components and blood cell tangible components prepared from healthy human plasma or specially immunized human plasma, separated, purified or prepared by recombinant DNA technology Classification of existing varieties: human albumin, human placental albumin, intravenous immunoglobulin, intramuscular immunoglobulin, histamine immunoglobulin, specific immunoglobulin, hepatitis B immunoglobulin, rabies immunoglobulin, tetanus immunoglobulin, human coagulation factor Ⅷ, human prothrombin complex, human fibrinogen, anti human gonorrhea There are 13 kinds of products such as immunoglobulin The products under clinical research include lyophilized human thrombin, S / d-ffp, antithrombin - Ⅲ, external lyophilized human fibrin adhesive, etc Albumin products usually refer to albumin products with a concentration of 20-25g / dl It is mainly used to correct the acute reduction of blood volume caused by large-scale operation, trauma, organ transplantation, etc.; to deal with the imbalance of body fluid water, electrolyte and colloid caused by large-scale burn, respiratory distress, etc., so as to prevent and control shock; hypoproteinemia, etc Immunoglobulin: it is mainly used for the prevention of some viral infectious diseases, such as hepatitis A and measles Specific immunoglobulin: compared with normal human immunoglobulin, it has the advantages of more reliable prevention effect, and some have positive treatment effect Intravenous immunoglobulin products have good tolerance to large doses of intravenous injection when used In addition, the virus inactivation step is added in the production process to improve the safety The clinical indications are increasing and the application is becoming more and more extensive It is the leading product in the blood products industry today Fibrin adhesive for coagulation factor products: used in plastic surgery, microsurgery, neurosurgery and other fields The product is inactivated by virus in the production process, which improves the safety of use Factor Ⅷ product is used to treat hemophilia A a Factor Ⅷ products with specific activity of 0.2-1.0iu/mg protein and 10iu / mg protein of medium purity and high purity are not only small in size, high in potency and convenient for home use, but also with higher purity and virus inactivation in the production process, so there are less adverse reactions in use and higher in safety Prothrombin complex concentrate contains four coagulation factors Ⅱ, Ⅶ, ⅸ and Ⅹ It is not only used for the treatment of hemophilia B with congenital factor IX deficiency and rare congenital factor Ⅶ and Ⅹ deficiency, but also for the treatment of acquired haemorrhagic diseases with multiple coagulation factors deficiency such as liver disease and hemophilia A with factor Ⅷ inhibitor 2 In recent years, the development of blood products from 2008 to 2015 ranked the top 7 in the blood products batch volume It can be seen that the batch volume of human albumin is far larger than that of other blood products, and it shows a high-speed rise trend The batch volume of immunoglobulin in rabies patients in 15 years decreased significantly The batch quantity of hepatitis B human immunoglobulin, tetanus human immunoglobulin and human immunoglobulin basically does not change every year They are basically in the saturation period of the market The annual batch quantity of intravenous immunoglobulin (pH4) and human serum albumin is on the rise They are in the unsaturated period of the market, that is, the demand of the market is far greater than the supply of the market In the past few years, the number of human serum albumin and intravenous immunoglobulin (pH4) batches will still rise In recent years, the number of batches of imported blood products has continued to increase and maintain its high growth rate The development of blood products is more and more fierce, and the market demand is more and more big, which makes it develop rapidly In the high development, human serum albumin has sprung up and occupied the leading position in the sales volume of blood products Analysis of biological blood products - specification analysis of human blood albumin (1) specification analysis of human blood albumin imported and domestic specification analysis, it can be seen that the market specification of human blood albumin accounts for the largest proportion of 10G (20%, 50ml), accounting for more than 70% of the whole Chinese market, so we can judge that the mainstream market specification of human blood albumin is 10g (20%, 50ml) (2) Prediction and analysis of human serum albumin time series batch quantity trend in 2008-16, it can be seen that the market of human serum albumin is still in short supply, and the market demand is also growing, so the market of biological products has not reached saturation, so the prospect of human serum albumin in the next few years is still very good After 2008, in the third quarter of each year, the batch issuance volume of human albumin is the highest in the whole year, and the batch issuance volume is the lowest in the first quarter of each year This trend will be a good trend feature for the future prediction The ARIMA (3,1,3) model was used to predict the future of human serum albumin, and the volume of human serum albumin batch issued in the next three quarters was obtained As can be seen from the figure, the predicted value of the model meets the trend of historical data Note: This article is the original manuscript of the author of yaozhi.com, welcome to reprint, please indicate the source and author when reprint, thank you!