Blood replacement is effective in reducing inflammatory responses

BEIJING, Aug. 25 (Xinhua Zhang Mengran) Britain's Nature Communications magazine published on the 25th of a new breakthrough in neuroscience, U.S. scientists used the whole blood obtained from healthy mice, replacing the blood of stroke model mice, successfully reduced the latter systemic inflammatory response. The findings provide important information for the medical community on blood replacement and could also advance the development of treatments for brain diseases.
Many neuropathic brain diseases can cause systemic reactions outside the brain, such as stroke, one of the world's most important deadly diseases and one of the most socially resource-intensive, that can cause damage to the blood-brain barrier and, in turn, systemic inflammatory response syndrome. The disease to brain isoemia and hemorrhagic injury symptoms as the main clinical manifestations, has been very high death rate and disability rate, but the disease long-term lack of effective treatment measures, can only be considered as the best measures.
this, a team at the University of West Virginia in the United States demonstrated in a series of experiments involving 333 male mice that blood replacement therapy can reduce this systemic response. They have shown that this result may be due to blood replacement reducing the level of a protein called the substring metal protease-9 (MMP-9).
known to increase MMP-9 levels in the blood of mice (and humans) within the first few hours of a stroke. By performing blood replacement therapy about six-and-a-half to seven hours after a stroke in mice, the team found that the volume of infarction (the area of tissue in the brain that died from a lack of blood supply) decreased and neurological deficiencies improved.
, the researchers also found that after blood replacement, mice had fewer MMP-9s in their blood and fewer inflammation-related proteins and immune cells. Blood replacement did not improve stroke symptoms when the researchers artificially added MMP-9 to the blood of healthy-supply mice before giving them a blood transfusion.
, these results suggest that blood replacement lowers levels of inflammation by lowering MMP-9 levels in the blood and brain after a stroke in mice, the researchers said.