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    Home > Active Ingredient News > Anesthesia Topics > BMC Anesthesiology: The effect of two different doses of thiopental on the adequacy of the depth of maternal anesthesia during elective cesarean section: a randomized clinical trial

    BMC Anesthesiology: The effect of two different doses of thiopental on the adequacy of the depth of maternal anesthesia during elective cesarean section: a randomized clinical trial

    • Last Update: 2021-09-03
    • Source: Internet
    • Author: User
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    background

    background

    In cesarean section, it is very important to give the best dose of anesthetic to ensure sufficient depth of anesthesia and to avoid adverse effects on the fetus
    .


    In some countries, thiopental is still the drug of choice for induction of anesthesia in obstetric surgery


    method

    method

    In this clinical trial, we randomly divided women who received elective cesarean section into two groups, receiving low-dose (5mg/kg) and high-dose (7mg/kg) thiopental sodium
    .


    Choose 2mg/kg succinylcholine as muscle relaxant, and maintain anesthesia with O2/N2O and sevoflurane


    result

    result

    Forty parturients in each group were evaluated.
    In the high-dose group, the BIS was significantly lower when the skin was incised before delivery and when the skin was sutured
    .


    In addition, in the use of the isolated forearm technique, there are also significant differences in the responses of the two groups of mothers during the induction of the skin incision and during the delivery


    in conclusion

    in conclusion

    7mg/kg of thiopental sodium can create a deeper sedative effect for the mother, and the effect is better than that of 5mg/kg of thiopental sodium
    .


    However, it has a negative impact on the Apgar score and neurobehavioral test results of newborns


    Original source:

    Original source:

    Golnar Sabetian, Farid Zand, Fatemeh Mirhadi, et al.


    Adequacy of maternal anesthesia depth with two sodium thiopental doses in elective caesarean section: a randomized clinical trial.
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