BMJ: New discovery-eating fat like this will keep you away from migraines!

Migraine is one of the biggest causes of disability in the world

Migraine is one of the biggest causes of disability in the world

N-3 and n-6 ​​fatty acids are the main components of tissues related to the pathogenesis of migraine.

Research this year has shown that several oxygenated lipids derived from n-6 fatty acids have compensatory (pain-promoting) properties

Several oxylipid substances derived from n-6 fatty acids have compensatory (pain-promoting) properties .

Several grass lipid compounds derived from n-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have powerful anti-pain (reducing pain) properties

The relationship between dietary n-6 and n-3 fatty acids and their oxidized lipid derivatives and the pathogenesis of headache

The relationship between dietary n-6 and n-3 fatty acids and their oxidized lipid derivatives and the pathogenesis of headache

So, without increasing n-3 fatty acids and not reducing n-6 linoleic acid, can dietary interventions change the circulating lipid mediators involved in the pathogenesis of headaches and reduce headaches in adult migraine patients? Experts from the National Institute of Aging under the National Institutes of Health recently gave their answers in the journal BMJ

Researchers from the American Academic Medical Center designed a three-arm, parallel group, randomized, modified double-blind, controlled trial for 16 weeks

H3 diet (n=61) -Increase EPA+DHA to 1.

H3 diet (n=61) H3 diet (n=61)

H3-L6 diet (n=61) - Increase n-3 EPA+DHA to 1.

H3-L6 diet (n=61) H3-L6 diet (n=61)

Control diet (n=60) - Maintain EPA+DHA at <150 mg/day, and linoleic acid at about 7% of energy

Control diet (n=60) Control diet (n=60)

The influence of diet on precursor fatty acids: the distribution of three precursor fatty acids in red blood cells and immune cells

The influence of diet on precursor fatty acids: the distribution of three precursor fatty acids in red blood cells and immune cells

The results showed that in the intention-to-treat analysis (n=182), compared with the control diet, the H3-L6 and H3 diets increased 17-HDHA (the average difference was 0.

H3-L6 and H3 diets increased 17-HDHA (mean difference 0.

The effect of diet on oxidized lipids and CGRP: The final measured distribution of oxidized lipids and CGRP in plasma

The effect of diet on oxidized lipids and CGRP: The final measured distribution of oxidized lipids and CGRP in plasma
.

Compared with the control group, H3-L6 and H3 diets reduced the total daily headache time (respectively -1.
7, 95% CI: -2.
5 to -0.
9, and -1.
3, 95% CI: -2.
1 to -0.
5), Moderate to severe headache time per day (-0.
8, 95%CI: -1.
2~-0.
4, and -0.
7, -1.
1~-0.
3) and number of headache days per month (-4.
0, -5.
2~-2.
7, and- 2.
0, -3.
3~-0.
7)
.

H3-L6 and H3 diets reduced the total daily headache time (respectively -1.
7, 95% CI: -2.
5 to -0.
9, and -1.
3, 95% CI: -2.
1 to -0.
5), moderate to severe daily Headache time (-0.
8, 95%CI: -1.
2~-0.
4, and -0.
7, -1.
1~-0.
3) and the number of headache days per month (-4.
0, -5.
2~-2.
7, and -2.
0, -3.
3~- 0.
7)
.
H3-L6 and H3 diets reduced the total daily headache time (respectively -1.
7, 95% CI: -2.
5 to -0.
9, and -1.
3, 95% CI: -2.
1 to -0.
5), moderate to severe daily Headache time (-0.
8, 95%CI: -1.
2~-0.
4, and -0.
7, -1.
1~-0.
3) and the number of headache days per month (-4.
0, -5.
2~-2.
7, and -2.
0, -3.
3~- 0.
7)
.

Among them, H3-L6 can reduce the number of headache days per month better than H3 diet (-2.
0, 95% CI: -3.
2~-0.
8), which indicates that reducing the linoleic acid in the diet will bring additional benefits
.
The H3-L6 and H3 diets changed n-3 and n-6 ​​fatty acids and their several nociceptive oxidized lipid derivatives in plasma, serum, red blood cells or immune cells, but did not change the classic headache mediators CGRP and PGE2
.

Reducing the linoleic acid in the diet will bring additional benefits.
Reducing the linoleic acid in the diet will bring additional benefits.

It can be seen that H3-L6 and H3 interventions have changed the biologically active mediators involved in the pathogenesis of headaches, reducing the frequency and severity of headaches
.

H3-L6 and H3 interventions changed the biologically active mediators involved in the pathogenesis of headaches, reducing the frequency and severity of headaches
.
H3-L6 and H3 interventions changed the biologically active mediators involved in the pathogenesis of headaches, reducing the frequency and severity of headaches
.

 

references:

Dietary alteration of n-3 and n-6 ​​fatty acids for headache reduction in adults with migraine: randomized controlled trial.
BMJ 2021;374:n1448

Dietary alteration of n-3 and n-6 ​​fatty acids for headache reduction in adults with migraine: randomized controlled trial.


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