BMJ: One in five people suffers from it-marijuana is a "turning over" in the treatment of chronic pain

Chronic pain affects approximately 20% of the adult population and is associated with physical and emotional impairment, disability, reduced quality of life, and increased medical costs

Chronic pain affects approximately 20% of the adult population and is associated with physical and emotional impairment, disability, reduced quality of life, and increased medical costs

Researchers have found that the systematic reviews supporting these guidelines have several limitations, including the exclusion of certain types of medical marijuana, consideration of selected chronic pain conditions, or incomplete search strategies

In order to determine the benefits and harms of medical marijuana and cannabinoids for chronic pain, experts from the Department of Anesthesiology at McMaster University in Canada conducted a systematic review and meta-analysis

Researchers searched MEDLINE, EMBASE, AMED, PsycInfo, CENTRAL, CINAHL, PubMed, Web of Science, Cannabis-Med, Epistemonikos and other databases for trials as of January 2021, and selected medical marijuana or cannabinoids with a follow-up period of ≥ 1 month Randomized clinical trial of chronic pain compared with any non-cannabis

The final inclusion included 32 trials involving 5174 adult patients, 29 of which compared medical marijuana or cannabinoids with placebo

Include reviewed studies on medical marijuana or cannabinoids in patients with chronic pain

The results showed that compared with placebo, non-inhaled medical marijuana may cause a 10% increase in the proportion of patients with a minimum important difference (MID) of 1cm (10cm visual analog scale (VAS)) in pain relief, based on a weighted average difference ( WMD) is -0.

Compared with placebo, non-inhaled medical marijuana may cause a 10% increase in the proportion of patients with the smallest significant difference (MID) of 1cm (10cm visual analog scale (VAS)) in pain relief.

Pain relief on VAS for chronic pain patients receiving non-inhaled medical marijuana or cannabinoids

However, oral medical marijuana does not improve mood, role or social function (highly certain)

Oral medical marijuana may cause symptoms such as transient cognitive impairment, vomiting, drowsiness, impaired concentration, and nausea, but no diarrhea

In summary, compared with placebo, non-inhaled medical marijuana or cannabinoids can improve the pain relief, physical function and sleep quality of patients with chronic pain

references:

Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials.

Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials.


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