BMJ sub-journal: Chinese scholars find that drinking more coffee reduces the risk of prostate cancer in men

Written | Edited by Wang Cong | Typesetting by Wang Duoyu | Shui Chengwen Several studies over the past few years have shown that drinking more coffee can bring many health benefits.
For example, drinking coffee is associated with a lower relative risk of liver, bowel, and breast cancer
.

According to the latest forecast data released by the World Health Organization's International Agency for Research on Cancer (IARC), prostate cancer in men worldwide will increase by 1.
41 million in 2020, making it the second most common malignant tumor in men worldwide (after lung cancer at 144%).
million)
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Three-quarters of prostate cancer cases occur in developed countries in Europe and America, but new cases of prostate cancer have risen sharply in Asian countries including Japan, Singapore and China since the 1970s
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In 2015, the incidence of prostate cancer in Shanghai surpassed that of liver cancer for the first time, ranking fourth in the incidence of malignant tumors in men in Shanghai, close to that of developed countries in Europe and the United States, seriously threatening the life and health of men
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Wang Kefeng and others from Shengjing Hospital Affiliated to China Medical University published in BMJ Open the title: Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis.
The paper [1]
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The study included 16 prospective cohort studies of 57,732 prostate cancer cases and found that higher coffee consumption was significantly associated with lower prostate cancer risk
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This study suggests that increasing coffee intake may reduce the risk of prostate cancer
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Previous research has linked coffee consumption with a lower relative risk of liver, bowel and breast cancer, but so far there has been no conclusive evidence on whether coffee drinking has a potential role in reducing the risk of prostate cancer
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To investigate the association between coffee intake and prostate cancer risk, the research team searched databases of relevant cohort studies published up to September 2020
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Sixteen studies were included, seven in North America, seven in Europe, and two in Japan, with a total cohort of more than 1 million men, 57,732 of whom had prostate cancer
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The results of the statistical analysis showed that compared with low coffee consumption (less than 2 cups per day), people with high coffee consumption (two or more cups per day) were associated with a 9% lower risk of prostate cancer, and for each additional cup of coffee per day, the prostate 1% lower cancer risk
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Further refining the analysis of localized and advanced prostate cancer showed that compared with low coffee consumption (less than 2 cups per day), men with high coffee consumption (two or more cups per day) had a 7% lower risk of localized prostate cancer, advanced stage and 12%-16% lower risk of fatal prostate cancer
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Overall, the risk of prostate cancer decreased with an increase in the number of cups of coffee consumed per day.
The research team believes that the caffeine in coffee can improve glucose metabolism, has anti-inflammatory and antioxidant effects, and can affect sex hormone levels, coffee These effects of prostate cancer may affect the occurrence, development and progression of prostate cancer
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Overall, this study suggests that increased coffee consumption may be associated with a lower risk of prostate cancer
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However, further studies are still necessary to determine the underlying mechanisms and the key active substances at work
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If the association between coffee consumption and prostate cancer risk reduction is further proven to be causal, men may be encouraged to increase coffee consumption to reduce prostate cancer risk
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In addition, several recent studies have shown that drinking coffee is associated with a reduced risk of disease
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Drinking more coffee reduces the risk of chronic diseases On July 23, 2020, the New England Journal of Medicine (NEJM), the first of the four major medical journals, published a review paper entitled: Coffee, Caffeine, and Health [2]
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The paper pointed out that there is substantial evidence that drinking coffee does not increase the risk of cardiovascular disease and cancer, and drinking 3 to 5 cups of coffee a day is associated with a reduced risk of several chronic diseases
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Drinking more coffee increases the survival of patients with colorectal cancer.
: Research paper of Association of Coffee Intake With Survival in Patients With Advanced or Metastatic Colorectal Cancer [3]
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The research team further analyzed observational data from a large clinical trial of colorectal cancer patients and found that among 1,171 patients with metastatic colorectal cancer who received treatment, those who drank 2-3 cups of coffee a day had longer overall survival and cancer.
The risk of exacerbation was lower, and the benefit was greater for patients who drank 4 cups of coffee a day
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On August 14, 2020, a number of Australian research institutions cooperated and published an article entitled: Estimates of the global reduction in liver disease‐related mortality with the journal Alimentary Pharmacology and Therapeutics.
Paper on increased coffee consumption: an analysis of the Global Burden of Disease Dataset [4]
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Analysis of the Global Burden of Disease dataset shows that liver cancer-related mortality declines globally as coffee intake increases, specifically, if every person in the world drinks at least two cups of coffee per day Liver cancer deaths will be reduced by more than 450,000, and if everyone drinks at least four cups of coffee a day, liver cancer deaths will be reduced by more than 720,000
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Special reminder: This article only interprets relevant research papers truthfully and does not constitute any purchase or use recommendation
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Paper link: 1.
https://bmjopen.
bmj.
com/content/11/2/e0389022.
https:// https://jamanetwork.
com/journals /jamaoncology/article-abstract/27702624.
https://onlinelibrary.
wiley.
com/doi/full/10.
1111/apt.
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