Br J Cancer: 5-aminolevulinic acid increases mitochondrial reactive oxygen species production and reduces radioresistance in prostate cancer

Prostate cancer (PCA) is one of the most common cancers in men worldwide, with a lifetime risk of about 13% and a mortality rate of 20%

Previous studies have shown that ionizing radiation (IR) can induce cancer cell death by two distinct mechanisms, including the direct effect of DNA damage and the indirect antitumor effect associated with reactive oxygen species (ROS) production

Previous studies have found that several RT sensitizers can overcome hypoxia-induced RT resistance by enhancing mitochondrial ROS levels

5-ALA has currently been used as a photosensitizer in photodynamic therapy (ALA-PDT)

The researchers aimed to investigate whether 5-ALA could increase the sensitivity of prostate cancer cells to radiotherapy by generating ROS through its metabolite PpIX

Treatment of cells with 5-ALA rapidly enhanced mitochondrial ROS production after exposure to IR and decreased mitochondrial membrane potential by upregulating intracellular PpIX levels

The therapeutic strategy of 5-ALA combined with radiotherapy can improve the therapeutic effect of radiotherapy on prostate cancer The therapeutic strategy of 5-ALA combined with radiotherapy can improve the therapeutic effect of radiotherapy on prostate cancer

 

Original source:

Original Source: Original Source:

Owari, T.

Owari, T.
, Tanaka, N.
, Nakai, Y.
et al.
5-Aminolevulinic acid overcomes hypoxia-induced radiation resistance by enhancing mitochondrial reactive oxygen species production in prostate cancer cells.
Br J Cancer (01 April 2022).
https: //doi.
org/10.
1038/s41416-022-01789-4.


Leave a message here