Br J Cancer: CYP3A7 rs45446698 SNP: Factors associated with pre-menopaan estrogen and progesterone levels associated with hormone-positive breast cancer risk

Epidemiological studies currently provide strong evidence for the role of hormones in the cause of breast cancer.
Prospective study data summary analysis shows that in post-menopto-menoptotic women, the multiplies of estamol or estrogen in the body cycle were associated with an increased risk of breast cancer, which increased by about 30-50%, while in pre-menopornal women, the risk of breast cancer increased by 20-30%.
previous studies have shown that pre-menovascular progesterone levels are associated with a risk of breast cancer.
previous studies have screened 642 related SNPs, including 42 genes involved in steroid synthesis or metabolism, and tested their correlation with pre-menotinal urethrogen-3-glucosides and progesterol-3-glucosides.
estrogen-3-glucosides and progesterol-3-glucosides are urine metabolites of estrogen and progesterone, respectively, in a study designed to identify genetic mutations associated with levels of sex hormones in the urine and the risk of breast cancer.
SNP and estrogen-3-glucosides levels were studied throughout the genome by researchers in Manhattan, and further analyzed progesterone levels in 298 pre-menopolytic women for 560 pre-menophatose-3-glucosides and progesterol-3-glucosides.
to test the association's association's 90,916 cases and 89,893 controls, the researchers analyzed genotypes.
are all European samples selected above.
results showed that there was no significant genome-wide association with glycol-3-glucosides.
for estrogen-3-glucosides, the researchers identified a single peak map of the CYP3A gene constellation and annotated rs45446698.
relationship between rs45446698 and estrogen-3-glucosides, glycol-3-glucosides and progesterone levels in pre-menophacean women, rs45446698-C, etc. The bit gene was associated with lower estrogen-3-glucosine levels, and in follow-up analysis, the rs45446698-C allephase gene was also associated with lower progesterone levels, estrogen and progesterone-positive breast cancer risk.
Overall, the Rs45446698 C allethroid gene on the CYP3A7 gene is associated with a reduced risk of hormone-positive breast cancer, possibly by affecting the metabolism of endogenetic hormones in pre menopaus women.