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Br J Cancer: Hormone levels before and after menopause are associated with the risk of invasive breast cancer

 Last Update: 2021-05-20
 Source: Internet
 Author: User

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Breast cancer is one of the most common cancers in women worldwide, and it is hormone-dependent.
In postmenopausal women, hormone replacement therapy and obesity increase the risk of breast cancer.

Breast cancer is one of the most common cancers among women in the world, and it is hormone-dependent.
Breast cancer is one of the most common cancers among women in the world, and it is hormone-dependent.
Breast cancer

Previous studies have shown that certain endogenous hormones can play a vital role in cancer by promoting cell proliferation and increasing the risk of random genetic errors.
Some endogenous hormones have been confirmed to be related to the risk of breast cancer, but the essence of these relationships is not fully understood.

Certain endogenous hormones can play a vital role in cancer by promoting cell proliferation and increasing the risk of random genetic errors.
Certain endogenous hormones can play a vital role in cancer by promoting cell proliferation and increasing the risk of random genetic errors.

In this study, the researchers measured the hormone concentrations in serum collected by the UK Biobank during 2006–2010 and repeated sub-samples (N≈5000) collected during 2012–13, and linked the data Identify sudden cancers.
The study aims to assess the relationship between the levels of various hormones and the risk of breast cancer.

The study aims to assess the relationship between the levels of various hormones and the risk of breast cancer.
The study aims to assess the relationship between the levels of various hormones and the risk of breast cancer.

Correlation between hormone and SHBG levels in premenopausal women and the risk of invasive breast cancer

The results showed that during the median follow-up time of 7.
1 years, 527 and 2,997 of 30,565 premenopausal women and 133,294 postmenopausal women were diagnosed with invasive breast cancer, respectively.
Researchers found that the risk of cancer in postmenopausal women was positively correlated with testosterone levels, while there was no correlation in premenopausal women.

diagnosis

The average concentration of total estradiol in each stage of the menstrual cycle in premenopausal women

Further research has shown that the risk of cancer is positively correlated with the level of IGF-1 (insulin-like growth factor 1) and negatively correlated with SHBG (sex hormone binding globulin).
It is only in premenopausal women that estradiol has nothing to do with the risk of disease, but there are still few studies on this hormone.

All in all, this study confirmed that testosterone, IGF-1 and SHBG are related to the risk of breast cancer, and that the heterogeneity due to menopausal status is related to testosterone.

This study confirmed that testosterone, IGF-1 and SHBG are related to the risk of breast cancer, and that the heterogeneity due to menopausal status is related to testosterone.

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