Br J Cancer: Sloan Project UK: 11337 breast catheter in-place cancer (DCIS) screening and pathological characteristics of subsequent events

Breast catheter in-place cancer (DCIS) is a heterogeneous disease that is increasingly diagnosed in breast cancer screening.
NHS BSP invites women aged 50-70 to breast cancer screening twice every 50 years.
The Sloane Project, established in memory of breast cancer pathologist Professor John Sloane, is a forward-looking cohort study that examines the clinical, imaging and pathological characteristics, care and outcomes of non-intrusive breast cancer patients screened in NHS BSPs.
the study is a national prospective cohort study that screens patients diagnosed with DCIS between 2003 and 2012 and compares their pathology, follow-up management, and results.
study of the risk of developing the same side breast catheter cancer (left) and indulging cancer (right) each year in patients undergoing breast care surgery (BCS) showed that 7,204 (64%) of the 11,337 patients had high-level DCIS.
Over time, the proportion of high-level DCIS increased (from 60 to 65 percent), the proportion of low-level DCIS decreased (from 10 to 6 percent), and the average size of tumors increased (from 21.4mm to 24.1mm).
of low-level DCIS (36%) patients is more common than in low-level DCIS (15%).
a small number (6%) of patients who underwent breast-feeding surgery (BCS) had surgical cut-outs of 1mm.
The effects of radiation therapy on the same-sided secondary indentation cancer in breast cancer patients were diagnosed in 9191 women in England (with a medium follow-up of 9.4 years), with 7 per cent developing the same-sided breast DCIS or insulated malignancies, while 5 per cent developed lateral breast DCIS or leaching malignancies.
same-sided events were immersive cancer (n s 413), with a medium time of 62 months, followed by DCIS (n s 225) and a medium time of 37 months.
radiotherapy (RT) is the most protective of recurrence of high-level DCIS (3.2% in patients with high-level DCIS receiving RT, compared with 6.9% in high-level DCIS patients without RT treatment, and 2.3% and 3.0% in low/medium-level DCIS, respectively).
further studies have shown that the DCIS event on the same side decreased after 5 years, while the risk of the same side immersion cancer continued for more than 10 years.
, the findings reveal that the pathological characteristics of DCIS contribute to patient management and emphasize the need for long-term follow-up in DCIS patients.
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