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BRAIN: Differences in functional connectivity of specific brain regions distinguish cervical dystonia from blepharospasm

 Last Update: 2022-05-24
 Source: Internet
 Author: User

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Neuroimaging studies reveal that dystonia is a movement disorder that causes involuntary muscle contractions, abnormal posture, and tremors with a variety of clinical manifestations

Costanza Giannì et al.

This cross-sectional study applied a multimodal 3T MRI approach, using 3D T1-weighted images to extract brain volume and cortical thickness, using a resting fMRI seed point-based approach to investigate the FC approach of the dentate and globus pallidus and whole-brain FC versus FC.

The study included 33 patients (17 CD [14 women] age 55.

The study yielded the following results:

Cervical dystonia (CD) patients and healthy people (HS) (A), blepharospasm (BSP) patients and HS (B), cervical dystonia (CD) patients and BSP patients (C) dentate nucleus resting function Connection (rsFC) graph comparison

Resting-state functional connectivity (rsFC) maps of the globus pallidus in healthy subjects (HS) (A), patients with cervical dystonia (CD) (B), and patients with blepharospasm (BSP) (C)

Cervical dystonia (CD) patients and healthy people (HS) (A), blepharospasm (BSP) patients and HS (B), cervical dystonia (CD) patients and BSP patients (C) patients with resting state function of the globus pallidus Comparison of connection (rsFC) graphs

There were no differences in cortical or subcortical volume between CD patients, BSP patients, and HC

In conclusion, this study found that both CD patients and BSP patients showed changes in the FC of the dentate nucleus, globus pallidus, and cerebellar-basal ganglia-thalamo-cortical sensorimotor circuits, supporting that focal dystonia is a network-specific disorder concept

original source
Giannì C, Pasqua G, Ferrazzano G, et al.

Giannì C, Pasqua G, Ferrazzano G, et al.
Focal Dystonia: Functional Connectivity Changes in Cerebellar-Basal Ganglia-Cortical Circuit and Preserved Global Functional Architecture.
Neurology .
2022;98(14):e1499-e1509.
doi:10.
1212/WNL .
0000000000200022 Giannì C, Pasqua G, Ferrazzano G, et al.
Focal Dystonia: Functional Connectivity Changes in Cerebellar-Basal Ganglia-Cortical Circuit and Preserved Global Functional Architecture.
Neurology .
2022;98(14):e1499-e1509.
doi:10.
1212 /WNL.
0000000000200022 Neurology

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