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There is no doubt that sleep is essential to human life, including cognitive function.
There is no doubt that sleep is essential to human life, including cognitive function.
Later, through two-photon microscopy, scientists found that sleep increased the volume fraction of the interstitium of the brain by 60%, which increased the clearance of amyloid-β in the cerebral cortex by a factor of two.
It was found that sleep increased the volume fraction of the interstitium of the brain by 60%, which increased the clearance of amyloid-β in the cerebral cortex by a factor of two.
It was previously demonstrated in a mouse AD model that after acute sleep deprivation, the brain levels of A-β (a metabolic byproduct of neuronal activity) increase, and chronic sleep deprivation increases the formation of A-β.
Subsequently, studies have successively reported that in healthy people, undisturbed sleep leads to a 6% reduction in the level of A-β42 in the brain.
In healthy people, undisturbed sleep leads to a 6% reduction in A-β42 levels in the brain.
The researchers injected the subject with intrathecal contrast agent (gadolinium, 0.
The enrichment of the brain tracer was compared between the two groups; one group (n = 7) received complete sleep deprivation from day 1 to day 2 (sleep deprivation group), and age and gender matched The control group (n = 17; sleep group) was allowed to sleep freely from day 1 to day 2.
The results showed that the concentration of tracers in the brains of the two groups was similar.
One night’s sleep deprivation impaired the removal of tracer substances in most brain areas, including the cerebral cortex, white matter, and limbic system, which could be observed in the morning of the second day after the intervention.
This result shows that complete sleep deprivation overnight will impair the human brain's "junk" removal function, and replenishment cannot accelerate the compensation and removal ability.
references:
Per Kristian Eide, Vegard Vinje, Are Hugo Pripp, Kent-Andre Mardal, Geir Ringstad, oup.
oup.
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