Brain-specific lncRNA regulates nerve cell DNA damage

Recently, Wang Wenyuan's team from the Intersection Center of Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, in collaboration with Xu Jun's team from Shanghai Oriental Hospital affiliated to Tongji University, and Wang Jian's team from Huashan Hospital affiliated to Fudan University, reported and named a new brain-specific non-coding for the first time.
Ribonucleic acid (lncRNA) BS-DRL1 has revealed its involvement in the regulation of nerve cell DNA damage response and genome stability
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The weakening of DNA damage repair function is one of the main factors of the aging of cells, organs and living individuals
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In this study, the researchers elaborated on the mechanism of BS-DRL1 mediating neuronal genome stability: On the one hand, in the early stage of DNA damage response, BS-DRL1 and HMGB1 use opposite mechanisms to restrict the damage response protein.
Phosphorylation level keeps it within the normal range; on the other hand, during the damage repair stage, BS-DRL1 acts as a scaffold protein, recruiting related proteins to the damage site for repair, thereby maintaining the stability of the genome
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At the same time, in vivo and in vitro experiments have shown that the loss of BS-DRL1 will cause the primary cultured nerve cells, mouse cerebral cortex and Purkinje cells in the cerebellum to accumulate more DNA damage under injury induction, while unrepaired DNA damage is Under physiological conditions, it will also accumulate as the age of mice increases, which will cause specific nerve cells to gradually die with aging, suggesting that BS-DRL1 also plays a very important regulatory function in the physiological aging of nerve cells
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Researcher Wang Wenyuan told China Science Daily that this study shows that long-chain non-coding RNA regulates DNA damage responses in the nervous system and affects its aging process, and these effects are specific to brain regions and cell types, revealing the tissue specificity of lncRNA Expression has important physiological functions and is of great significance for subsequent lncRNA function research
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It is reported that the research team is currently conducting in-depth research on the role of BS-DRL1 in the aging process of nerve cells.
Wang Wenyuan said that the research will greatly promote people’s understanding of brain aging and brain aging-related motor and cognitive disorders.
Understand
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Related paper information: https://doi.