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If the carotid artery supplying the brain is compared to the crown of a tree, water is transported to each leaf through the branches from thick to thin, and the last branch is the "small cerebral blood vessel"
.
In a broad sense, small blood vessels in the brain refer to blood vessels in the deep part of the cerebral cortex with a diameter of <500μm.
In a narrow sense, they refer specifically to small blood vessels with a diameter of less than 200μm in the brain, whose thickness is equivalent to several hair strands
.
When these small blood vessels have disease, such as blockage or rupture, it will cause corresponding symptoms-this is cerebral small vessel disease (CSVD)
When these small blood vessels have disease, such as blockage or rupture, it will cause corresponding symptoms-this is cerebral small vessel disease (CSVD)
CSVD is also the most common main cause of vascular dementia in the world
.
Although there is evidence to confirm the relationship between inflammation and cerebrovascular disease, the mechanism link has not been elucidated
CSVD is also the most common main cause of vascular dementia in the world
The results showed that the plasma sTREM2 levels of AD patients and CSVD patients were similar (P=0.
690)
.
In CSVD patients, plasma sTREM2 was significantly related to WMH (P<0.
In CSVD patients, plasma sTREM2 was significantly related to WMH (P<0.
The relationship between plasma sTREM2 and white matter lesions, Tau burden and cognition
In summary, plasma sTREM2 is related to WMH, but has nothing to do with Aβ and tau pathology
.
These findings underscore the potential utility of plasma sTREM2 as a powerful predictor of white matter damage associated with small vessel disease, and has clinical significance for targeting innate immune responses in the treatment of this disease
In summary, plasma sTREM2 is related to WMH, but has nothing to do with Aβ and tau pathology
references:
Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau, Brain, 2021;, awab332, https://doi.
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