Brain: tau protein is related to the pathological progression, disease stage and memory performance of the medial temporal lobe subregions of AD patients

In Alzheimer’s disease, autopsy studies have shown that the first cortex where neurofibrillary tangles appear is the transentorhinal zone, which is a subregion of the medial temporal lobe, which roughly overlaps with Brodmann 35 zone.
The entorhinal zone is also In it
.

With the advent of tau-pet, it is possible to study the pathology of tau protein accumulation in the body
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David Berron et al.

David Berron et al.

The study used tau-pet imaging to study the pathological progression sequence of tau protein across regions of the human medial temporal lobe and posteromedial system
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To study the relationship between medial temporal lobe tau protein and functional connectivity, regional atrophy and memory performance

In the end, 215 individuals with amyloid-β cognitively impaired, 81 amyloid-β+ cognitively impaired, and 87 amyloid-β+ mild cognitively impaired individuals were accepted.
¹⁸ F-RO948 tau and ¹⁸ F-flutemamol amyloid PET imaging, structural T1-MRI and memory evaluation
.

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In the tau-EBM phase, voxel level tau-PET binding and voxel-based morphological measurement

In the tau-EBM phase, voxel level tau-PET binding and voxel-based morphological measurement

First, event-based modeling shows that the entorhinal cortex and Brodmann 35 area show the earliest signs of tau accumulation , followed by the anterior and posterior hippocampus, Brodmann 36 area and parahippocampal cortex
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In the later stages, the accumulation of tau protein in the neocortex, temporal lobe, and finally the parietal region of the brain becomes abnormal

The entorhinal cortex and Brodmann 35 area show the earliest signs of tau accumulation in the anterior and posterior hippocampus, Brodmann 36 area and the parahippocampal cortex

In individuals with unimpaired cognitive function, the increase in tau load is related to the local atrophy of the entorhinal cortex, Brodmann 35 area and the anterior hippocampus, while the tau load of several medial anterior subregions of the temporal lobe is associated with the distal atrophy of the posterior hippocampus

The relationship between MTL partition tau SUVR and shrinking

The relationship between MTL partition tau SUVR and shrinking

In addition, the reduction of the key network functional connections between the medial temporal lobe and the posteromedial system regions related to tau is related to this early memory impairment
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The reduction of the key network functional connections between the medial temporal lobe and the posteromedial system regions related to tau is related to this early memory impairment
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The relationship between MTL tau SUVR, memory performance and atrophy in cognitively unimpaired individuals and MCI patients

The relationship between MTL tau SUVR, memory performance and atrophy in cognitively unimpaired individuals and MCI patients

In patients with mild cognitive impairment, the correlation between tau load in the hippocampus and memory performance is partly mediated by posterior hippocampal atrophy
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In patients with mild cognitive impairment, the correlation between tau load in the hippocampus and memory performance is partly mediated by posterior hippocampal atrophy
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In summary, the results of this study highlight the pathological progression of tau protein in the medial temporal lobe subregion and the relationship between its disease stage and memory performance
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The tau protein may affect the memory performance of cognitively intact individuals by reducing the functional connection of the key medial temporal lobe-cortex network, and the memory impairment of patients with mild cognitive impairment is related to retrohippocampal atrophy

The results of this study highlight the pathological progression of tau protein in the medial temporal lobe subregion and the relationship between its disease stage and memory performance

Early stages of tau pathology and its associations with functional connectivity, atrophy and memory, Brain, Volume 144, Issue 9, September 2021, Pages 2771 –2783, https://doi.

Early stages of tau pathology and its associations with functional connectivity, atrophy and memory, Brain, Volume 144, Issue 9, September 2021, Pages 2771 –2783, https://doi.
org/10.
1093/brain/awab114 Early stages of tau pathology Functional Connectivity with the ITS Associations and, atrophy and Memory, Brain, Volume 144, Issue 9, September 2021, Pages and the 2771 -2 783, https://doi.
org/10.
1093/brain/awab114 in this message