Brain: What are the neuropathological lesions of COVID-19

Many patients infected with SARS-CoV-2 have neurological signs and symptoms; although so far, there is little evidence that primary infection of the brain is an important contributing factor
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Many patients infected with SARS-CoV-2 have neurological signs and symptoms; although so far, there is little evidence that primary infection of the brain is an important contributing factor
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Infect

Columbia University Peter Canoll et al.

published an article in Brain magazine and reported the clinical, neuropathological, and molecular findings of 41 consecutive deaths and autopsy of SARS-CoV-2 infection patients

Columbia University Peter Canoll et al.

The average age of the study subjects was 74 years (38-97 years), 27 patients (66%) were male, and 34 patients (83%) were Hispanic/Latino

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The average age of the study subjects was 74 years (38-97 years), 27 patients (66%) were male, and 34 patients (83%) were Hispanic/Latino

The clinical course of COVID-19 patients is divided by day

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The clinical course of COVID-19 patients is divided by day

Hospital-related complications during hospitalization were common, including 8 cases (20%) of deep vein thrombosis /pulmonary embolism, 7 cases (17%) of acute kidney injury requiring dialysis, and 10 cases (24%) of positive blood cultures

Acute focal hemorrhagic infarction in COVID-19 patients

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Acute focal hemorrhagic infarction in COVID-19 patients

 Neuropathological examination of 20-30 areas of each brain showed that all brains have hypoxic/ischemic changes, including whole brain and focal; large and small infarcts, many of which have hemorrhage; microglia activation With microglia nodules and neuronal phagocytosis, it is most obvious in the brainstem

Eighteen patients (44%) presented with neurodegenerative diseases, which is not surprising given the age range of the patients

qRT-PCR structure

qRT-PCR structure qRT-PCR structure

PCR analysis showed that in most brains, viral RNA levels are low to very low, but can be detected, although they are much lower than the levels in the nasal epithelium

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PCR analysis showed that in most brains, viral RNA levels are low to very low, but can be detected, although they are much lower than the levels in the nasal epithelium
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RNAscope and immunocytochemistry failed to detect viral RNA or protein in the brain
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RNAscope and immunocytochemistry failed to detect viral RNA or protein in the brain
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The results of the study showed that the level of detectable virus in the brain of COVID-19 is very low and has nothing to do with histopathological changes
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These findings indicate that the microglia activation, microglia nodules and neuron phagocytosis observed in most brains are not caused by the direct infection of the brain parenchyma by the virus, but more likely caused by systemic inflammation.
Synergistic effect with hypoxia/ischemia
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The results of the study show that the detectable virus levels in the brain of COVID-19 COVID-19 are very low and have nothing to do with histopathological changes
.
The level of detectable virus in the brain is very low and has nothing to do with histopathological changes
.
These findings indicate that the microglia activation, microglia nodules and neuron phagocytosis observed in most brains are not caused by the direct infection of the brain parenchyma by the virus, but more likely caused by systemic inflammation.
Synergistic effect with hypoxia/ischemia
.
The microglia activation, microglia nodules and neuron phagocytosis observed in most brains are not caused by direct infection of the brain parenchyma with viruses, but more likely caused by systemic inflammation, which may be related to hypoxia/ Synergistic effect of ischemia
.

 Original source

 Original source

COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital, Brain, Volume 144, Issue 9, September 2021, Pages 2696–2708, https://doi.
org/10.
1093/brain/awab148

COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital, Brain, Volume 144, Issue 9, September 2021, Pages 2696-2708, https://doi.
org/10.
1093/brain/awab148 Leave a message here