Scanning electron microscope image (blue) of group streptococcus (orange) and human neutrophils phagocytosis
Group B Streptococcus (GBS) bacteria are a common cause of neonatal blood infections, meningitis and stillbirth
"We have previously demonstrated that HMOs mixtures isolated from the breast milk of different mothers have anti-GBS antibacterial activity
According to data from the US Centers for Disease Control and Prevention, about 2,000 infants in the United States are infected with GBS each year, and 4% to 6% of them die from this disease
Researchers have found that formula-fed infants have a higher incidence of late infections (occurring between one week and three months after birth) than breast-fed infants, indicating that factors in breast milk can help prevent GBS
Researchers studied the effect of combined HMO from several mothers on GBS infection of placental immune cells (macrophages) and pregnancy membranes
In order to figure out which HMOs and other oligosaccharides have these antibacterial effects and why, the researchers established two artificial microbiomes, including GBS and beneficial Streptococcus salivary species grown on tissue culture plates, separated by semipermeable membranes
Somewhat surprisingly, the first HMO they tested in the system did not have this effect, but Townsend said that it is likely that one or more of the more than 200 unique sugars in breast milk were analyzed in the artificial microbiome.
"The history of health management organizations is as long as that of humans, and bacteria have not found them
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