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    Home > Biochemistry News > Biotechnology News > Broccoli anti-cancer real hammer? Look at this plant-derived classic anti-cancer drug and you'll see.

    Broccoli anti-cancer real hammer? Look at this plant-derived classic anti-cancer drug and you'll see.

    • Last Update: 2020-06-03
    • Source: Internet
    • Author: User
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    Photo Source: Web screenshotsbroccoli contains molecules not equal to broccoliin fact, about the broccoli anti-cancer news, the real scientific statement should be: scientists found that "broccoli and other crossflower plants in a natural molecule, can inhibit tumor growth." The researchers themselves said: "If you want to convert by equal amount, to achieve potential anti-cancer effects, about 6 pounds of vegetables per day."eat 6 pounds of broccoli a day, but also just "potential" anti-cancer effect (meaning there may or may not be), you are amusing me?remember a year of influenza outbreak, the public know That Tamiflu this treatment of influenza drugs, by the way also recalled the taste of octagonal fennel, because octagonal fennel is one of the raw materials for the production of TamifluSo there is eating octagonal fennel boiled pork can fight the flu, of course, we know that this is just a jokecrucified vegetables, including broccoli, are a good food and are recommended as part of a healthy diet in the dietary guidelinesBut eating broccoli to fight cancer, just like eating octagonal fennel boiled pork against influenza, can not play a real roleOf course, now that the molecules that inhibit tumors have been found in broccoli, scientists will continue to study, and perhaps in the future will actually develop an anti-cancer drug from broccoli, but not broccoli itself as an anti-cancer druga twist and turn of the "drug-seeking" story
    there are precedents in history, such as yew alcoholYew alcohol is now a commonly used anti-cancer drugIt comes from the bark of yew (also known as red bean fir) and can be used to treat breast cancer, lung cancer, ovarian cancer, etcthe history of the development of yew alcohol dates back to the 1960sAt that time, infectious diseases were under control, and the problems of cancer and cardiovascular disease salientSo the American Cancer Institute (NCI) has stepped up research and development of cancer drugs, with one measure to screen for cancer drug molecules from natural sources in plantswho to look for when you study plants? The Ministry of Agriculture, of course NCI found the U.S Department of Agriculture and asked researchers there to help find natural products that could cure cancer one day in August 1962, Dr Arthur Barclay, a botanist at the U.S Department of Agriculture, with several graduate students, took branches, fruit and bark from a 7-meter-tall Pacific yew tree in the heat say, humans have a very long history of using yews The ancient egyptian, Greek, Roman and other armies all had spears, bows and other weapons made of yews, and Britain found spear tips made of yews 50,000 years ago Three kings in British history have died from bows made of yews In 1856, people discovered yew alkali, known for the cause of the yew toxic but in general, the long history of human use of yew sequoia has little to do with yew alcohol to fight cancer So, Dr Barclay's August 1962 collection was not particularly purpose-based, just for "random tactics" and for a bit of a haystack they had collected the samples and sent them to designated research institutions There, the researchers found that a sample of yew bark had a toxic effect on cancer cells cultured in vitro So the NCI people to say hello to the Ministry of Agriculture, yew bark may have a play, and make more more, we also want to further evaluate In September 1964, Dr Barclay returned to his old place and collected more yew bark Who knows how many laboratories refused to receive, because they found that yew bark to cancer cells and normal cells are toxic, good or bad, this can not be used as a drug for patients ah Then Dr Monroe Wall of the Triangle Institute in North Carolina came forward and said, They don't want me, send it to us Dr Wall has developed anti-cancer drugs from other plant sources, which are also highly toxic, but Dr Wall has extracted a compound with medicinal potential , more fir bark samples were collected and sent to Dr Wall's team to identify and purify the most active ingredients 1966, researchers isolated a crystalline substance and named it yew alcohol As the name suggests, it is an alcohol compound extracted from yew But just as they thought they were close to success, they found that many of the compound's properties were uncertain, and even molecular weights could not be measured at this point, they've made progress in other studies, even going into clinical trials, and there are more plant extracts to evaluate There is too much work at hand to do, yew alcohol research is more difficult, may have to shelve However, Dr Wall's colleague, Dr Mansukh Wani, was reluctant to give up completely, so they took the lead in studying yew alcohol as they took other studies finally, Dr Wall and Dr Wani used a new technique that was still in infancy to understand the molecular structure of yew alcohol, and in 1971 published a simple paper declaring that the newly-clarified molecule was anti-tumor active it should be argued that this time should be able to speed up research, further animal experiments, followed by human clinical trials But the problem is here again When the bark was peeled off, the tree died, while a Pacific yew tree could only pick about 2 kg of bark, and according to the technology at the time, 12 kg of dry bark could only get 0.5 grams of yew alcohol As a result, there are bottlenecks in the supply of materials, and the study of yew alcohol is slow 1977, NCI confirmed the anti-tumor activity of yew alcohol in animal models of a variety of cancers Two years later, with the help of NCI, Dr Susan Horwitz discovered the principle of the anti-tumor effect of yew alcohol (previously only knowing that it can fight tumors, now knows why it is resistant to tumors) Because of the accumulation of evidence, the principle of clear, the scientific community's interest in yew alcohol has become strong then urgently needed a method that could produce a large quantity of yew alcohol One company has developed a way to extract the yew alcohol precursor from a more common yew and then chemically convert the precursor into yew alcohol The production of yew alcohol has finally gone, and clinical trials are possible Now, of course, yew alcohol is produced by cell culture, and no longer need to rely on yew trees but there's a big problem: yew alcohol is almost insoluble in water, making it difficult to make intravenous fluids The initial anti-tumor activity of yew alcohol is observed by suspending the raw material in the liquid, but this can not be used ah! Anti-tumor activity is strong again, with out of the patient's body or white good, after the preparation research and development team's groping, finally found a specially formulated solution, yew alcohol can be dissolved in it 1984, NCI began a Phase 1 clinical trial of yew alcohol against multiple types of cancer In 1989, researchers at Johns Hopkins University reported that the demand for yew alcohol surged after it caused partial or complete remission in 30 percent of patients with advanced ovarian cancer In December 1992, the U.S Food and Drug Administration (FDA) approved yew alcohol for the treatment of ovarian cancer Since then, the FDA has approved yew alcohol for the treatment of breast, lung, and more, based on more evidence of effectiveness in other cancers Until now, yew alcohol is still a commonly used chemotherapy drug In addition, scientists and doctors are studying new combination therapies, new uses, and new drugs based on yew alcohol red bean fir bubble sparkling wine is invalid and may be toxic
    we may see some articles on the Internet, said red bean fir bubble water, sparkling wine, can fight cancer, health Today, after seeing the research and development of yew alcohol, you will understand that even scientists with a special method, but also from the natural red bean fir (yew) can only extract a small amount of yew alcohol, from the household red bean fir bubble water, sparkling wine, can get the effective ingredients are very small, and there is the possibility of poisoning picture source: Web screenshots the above, from the discovery of potentially effective compounds in plants, to the development of a clinically available drug, it will take a long time, may encounter many unexpected difficulties Of course, drug development tools, methods and experience are better than in the 1960s and 1970s, and broccoli is much easier to obtain than yew trees We hope that scientists will succeed soon and bring more safe and effective medicines to patients! References 1 American Chemical Society RetrievedMay 23, 2019, from https://
    HoydMay 23, 2019, from https://dtp.cancer.gov/timeline/flash/success_stories/S2_taxol.htm
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