Caffeine Hazards: Memory Premature Aging.

In a new study, researchers from the Portuguese Institute of Molecular Medicine and France's National Institute of Health and Medical Research have revealed mechanisms for age-related cognitive impairment in caffeine-resistant animals.
results were published online August 11, 2016 in the journal Scientific Reports of the Nature Publishing Group under the title "The caffeine-binding adenosine A2A receptores age-like HPA-axis dysfunction by targeting glucocortic receptor function".
researchers have confirmed that abnormal expression of a specific receptor --- adenosine A2A receptor (adenosine A2A receptor, A2AR), a target for caffeine--- in rats, induces an aging-like condition, a memory defect associated with the loss of stress control mechanisms. "This is part of a large study that started four years ago, in which we identified the role of this subject in stress, but we don't know if its activation is enough to trigger all of these changes," explained Luisa Lopes, co-author of the
paper and head of the research team at the Portuguese Institute of Molecular Medicine.
We have now found that simply altering the level of this subject in neurons from the hippocemia and cortical ---refermination-related regions--- is enough to induce what we call 'early-aging': memory loss and an increase in the stress hormone (cortisol) in the plasma.
"memory and stress-related defects were normalized when these same animals were treated with a caffeine similarity that blocked A2AR's functioning."
, co-author of the paper and director of research at France's National Institute of Health and Medical Research, added, "We know that in older adults, levels of stress hormones that affect memory are increasing.
Our study supports the idea that A2AR antagonists, or caffeine, the cognitively promoting effects observed in Alzheimer's disease and age-related cognitive impairment may depend on its ability to resist the loss of stress control mechanisms that occur in aging.
"Luisa Lopes concludes, "Not only is it important to understand the fundamental changes that occur in aging, but it also identifies A2AR dysfunction as a key factor in triggering these changes."
it is a very attractive therapeutic target.
" Source: Supplied