Can antibiotics change the microbiome to make older animal arteries younger?

the source of youth in the gut microbiome? This is the title of an article published this year in the journal Journal of Physiology, which was inspired by a study in which researchers found that when older mice were given broad-spectrum antibiotics to inhibit the microbiome in their bodies, their body arteries functioned like those of young animals, and the results were similar to those of other researchers, who noted that the gut microbiome is a promising target that can help reduce the risk of cardiovascular disease in humans.Given the known effects of gut microbe metabolites on the body's cardiovascular system, the current findings are not very surprising; in human and animal studies, researchers have in recent years found that specific microorganisms can regulate the risk of disease in host bodies in a special way, often by interacting with the host's diet; although the researchers believe that antibiotics are an experimental tool and should not be seen as a potential way to promote cardiovascular health in humans, and in some cases researchers have investigated other methods to further analyze the interactions between the intestinal and cardiovascular systems. Now researchers have found that hundreds of compounds produced by the gut bacterium can be absorbed by the body, creating a biological effect on the host body.Good metabolites Bad metabolitesresearcher Stanley Hazen, a pioneer in mapping the effects of microbes on cardiovascular risk, found in 2011 that people who experienced a heart attack, stroke or death over the next three years were less likely to experience a heart attack, stroke or death. Levels of dietary lipid phosphatidylcholine metabolites rise, and the researchers also found that these metabolites can cause arteriosclerosis or atherosclerosis in mice, and that the harmful effects of metabolite choline on the mouse body may be suppressed if broad-spectrum antibiotics are given in advance.In subsequent studies, the researchers confirmed this relationship, noting that choline, a nutrient rich in animal products, can be converted by gut microorganisms into TMAO (triampartamine N-oxide) and other TMA (thamamine), metabolites Signals are sent to make plate plate plates more active and prone to hemolysis, which can trigger heart attacks or strokes in the body if blood clots are formed, while carnitine, a compound with higher levels in red meat, can be converted into TMA by gut bacteria just like choline.Other researchers have also studied how the gut bacteriota affects the body's cardiovascular health through TMAO, and researchers from the University of Gothenburg recently found that sterile mice may be less sensitive to aortic lesions, which may be a major feature of atherosclerosis, and that they are smaller than wild types. In mice, cholesterol levels were also low, and the difference disappeared when two groups of mice were given extra choline at the same time, suggesting that the microbiome may not be the main driver of atherosclerosis, at least in the mouse breeds studied by the researchers.researchers investigated the relationship between TMAO and gut microbes and found that levels of TMAO in the blood increased with the age of mice, along with changes in the composition of the mouse's body's microbiome, but it is not clear why this change occurs. If there is more inflammation in the body, perhaps the bacteria in the gut have a negative impact, researchers are currently conducting a study comparing the differences between people on western diets (high-fat, high-sugar, low-fiber) and those on low-fat, low-sugar and high-fiber diets to see if the latter diet can slow down changes in age-related microbiomes.Not all gut microbiomes have a negative impact on cardiovascular health, and researchers from the University of Wisconsin recently found that certain gut microbiomes have special protective effects, and last year researchers reported that the butyric acid-producing gut microbiome Roseburia intestinal is more likely to be It was planted in mice sensitive to atherosclerosis, and mice with special bacteria were less likely to develop aortic lesions than mice without the bacteria, and feeding the mice butyric acid also allowed them to produce lower levels of lesions.And another potentially protective strain is Bifidobacteria, and in 2017, researchers found that Bifidobacteria may be directly related to better vascular function in mouse bodies, and researchers wanted to examine a number of studies to see if Bifidobacteria fungus had a protective effect on mice.Sopen the gut microbiome researchers say probiotics may provide some protection for individuals who lack the corresponding protective gut microbiome, but this may not be a magic solution, meaning that we can stay healthy by taking probiotic-carrying pills, and that many microbes consume special nutrients that do not work if we do not consume nutrients that promote the development of beneficial gut microbiomes.Blocking the effects of harmful microorganisms is also a potential solution, and last year researchers identified a compound called FMC that blocks the function of enzymes produced by microbial TMA, but does not kill bacteria.Now scientists are continuing to delve into the link between the microbiome and the body's cardiovascular health, each of which has some clinical significance, for example, after studying animals, researchers have found that the short-chain fatty acids produced by bacteria when breaking down fibers interact with the host cell's ligands to regulate blood pressure, and while the microbiome is not the only medium for cardiovascular health, scientists working in the field suspect that there are many connections worth exploring.researchers say that with the deepening of scientists' research and the emergence of different studies, the gut microbiome will eventually become the most important and discoverable organ in the human body.:1 Opinion: AI Beats Animal Testing at Finding Toxic Chemicals2 Vienna E. Brunt, Rachel A. Gioscia Ryan, James J. Richey, et al,. Suppression of the gut microbiome ameliorates agerelated arterial dysfunction and oxidative stress in mice, Journal of Physioology, 04 February 2019, doi:10.1113/JP277336 .3) Gutflora metabolism of phosphatidylcholinepromotes cardiovascular4" Weifei Zhu, Jill C. Gregory, Elin Org, et al. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk, Cell (2016) doi:10.1016/j.cell.2016.02.011 Zeneng Wang, Nathalie Bergeron, Bruce S Levison, et al. Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women, European Heart Journal, Volume 40, Issue 7, 14 February 2019, Pages 583-594, doi:10.1093/eurheartj/ehy799 Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model "Development of a gut microbe-targeted nonlethal to reseed thrombosis potential 9" Jennifer L. Pluznick, Microbial Short Chain Fatty Acids and Blood Pressure Regulation, Curr Hypertens Rep. 2017 Apr;19 (4): 25. doi:10.1007/s11906-017-0722-5

10: The Gut Microbiome Can Be a Boon or a Bane for Cardiovascular Health Jul 10, 2019, SHAWNA WILLIAMS Source: E. coli and