Can aspirin improve breast cancer prognosis? Research shows that DNA modification works.

If women take aspirin before they are diagnosed with breast cancer, women with specific DNA characteristics in specific areas of the genome may live longer, new research suggestsDrTengteng Wang and her mentor, Marilie Gammon, of the University of North Carolina at Chapel Hill,, wanted to know whether DNA methylation would affect the effectiveness of aspirin in breast cancer patientsThe team tested DNA methylation in breast cancer tissue, including DNA sites that control the expression of 13 breast cancer-related genes, as well as cells in the patient's blood circulationNotably, this study is also the first to examine the effects of DNA methylation on the relationship between aspirin use and mortality in women with breast cancerhttps://doi.org/10.1002/cncr.32364after studying 1,266 women diagnosed with breast cancer between 1996 and 1997, the researchers found that by the end of 2014, 476 people had died from various causes and 202 from breast cancerAmong women taking aspirin, those who did not have methylation of DNA in areas that control the expression of the BRCA1 gene in breast cancer had a lower risk of dying from any cause and from breast cancerThe researchers also observed other patterns of methylation associated with aspirin use and mortality"using DNA methylation spectra as a potential modifier associated with aspirin mortality may provide new insights into the potential biological mechanisms between aspirin and post-cancer diagnosis mortality," DrWang said"If our findings are confirmed, it may be possible in the future to identify the patient by using epigenetic markers, which could affect clinical decision-making." For these patients, pre-diagnosis aspirin use can affect subsequent mortality and may help improve clinical treatment strategies to reduce the risk of death and improve survival rates," Added DrGammonKerry MMalecki, M.D., of the University of Wisconsin-Madison,, said in an accompanying editorial that the findings support the importance of interactions between epigenetics and low-cost therapies such as aspirin https://doi.org/10.1002/cncr.32365 Dr Malecki said: "Wang et al's research shows that, in addition to the interaction symofs between genes and the environment, epigenetic and environmental interactions exist, suggesting that DNA methylation may in the future help identify potentially effective individuals for treatment 1' aspirin may interact with with cells' DNA modifications to alter breast cancer s Can aspirin improve breast cancer prognosis? Research shows that DNA modification works.