Cancer Cell: One thing drops one thing!

TP53 is a key tumor suppressor gene and is usually inactivated by missense mutations in the DNA binding domain.

Recently, researchers from the Luis A Martinez project of Stony Brook University in the United States published a study titled Mutant p53 suppresses innate immune signaling to promote tumorigenesis in Cancer Cell, and found that mtp53 can inhibit innate immune signaling, thereby Causes immunity to escape.

To determine whether mtp53 regulates innate immune signaling pathways, the researchers first down-regulated the expression of mtp53 in human breast cancer cells BT549 (p53R249S), MDA-MB-231 (p53R280K) and pancreatic cell lines MIA PaCa.

Mutant p53 suppresses innate immunity

In the tumor microenvironment, the TBK1/STING/IRF3 pathway signals the presence of tumor cells to immune cells.

Mutant p53 can inhibit immune surveillance and promote tumor growth

Pattern diagram

In general, the study found a new mechanism.

Original source:

Monisankar Ghosh, et al.