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Lipid rafts are tightly packed, cholesterol and sphingomyelin-rich microdomains in the plasma membrane.
Recently, a research report entitled "Rafting Down the Metastatic Cascade: The Role of Lipid Rafts in Cancer Metastasis, Cell Death, and Clinical Outcomes" was published in the international journal Cancer Research.
Researchers have found that TRAIL can effectively kill these drug-resistant colon cancer cells.
Lipid raft structure plays an important role in cancer cell metastasis and cell death
Image source: Joshua D.
When colorectal cancer spreads to other organs of the body, the patient needs to receive chemotherapy.
In the later stage, researchers still need to conduct more drug discovery studies to change the structure of lipid rafts in cancer cells, thereby affecting its interaction with death receptors, and increasing the therapeutic benefits of TRAIL
Original source:
Joshua D.
