Cao Xuetao first mentioned the new concept of "look-a-view meta-control group"
Last Update: 2021-02-23
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February 6, Cao Xuetao, a member of the Chinese Academy of Engineering and president of Nankai University, was invited to publish a review article entitled "The Surface Remodeling of Natural Immunity and Inflammation" in the Yearbook of Immunology. It is reported that the Yearbook of The Review of Immunology is an international authoritative academic journal of immunology, an annual collection, published only the journal editorial board in accordance with the progress of international immunology research and invited well-known experts to write the manuscript.
This 32-page review paper first proposed a new concept of "Epiregulome" (epigenetic meta-control group): modification of various chromosome levels in various chromosome levels such as gene promoters, enhancers, etc., and the composition of binding proteins or non-coding RNA independent of genomic sequences, which creates a regional specific chromosomal state, thus critically regulating gene-specific expression and cellular characteristics.
Cao Xuetao introduced, this review focuses on this new concept, systematically expounds how the micro-environmental signals of tissue organs in the process of cell differentiation, development and stress can be constructed by constructing the cell "look-off metacontrolling group" to build the characteristic functional state of natural immune cells, so as to accurately regulate the natural immune and inflammatory response.
surface regulation is based on the chromosome level that does not depend on DNA sequences and involves the participation and regulation of related elements such as DNA, histones and other co-price modification, non-coding RNA and chromosomal binding proteins. The cross-regulation of various oscic modifications and their binding molecules determines the chromatin state of different regions of the genome and plays a key role in gene-specific expression regulation. Therefore, the observational regulation determines the establishment and change of cellular characteristic functional state in a variety of physiological and pathological processes, which is very important for the study of health maintenance and disease development. Cao Xuetao said.
why are natural immune cells the body's first line of defense against pathogen invasion? Why does the tissue microenve environment differentiate, develop, and mature natural immune cells to quickly identify pathogens and quickly activate immune response characteristics and abilities? After pathogen infection, how do natural immune cells go from an active state to a receding or toaling state, or even reinvented as "adaptive" natural immune cells to better respond to secondary infections? In recent years, analyzing how to accurately regulate the differentiation and development of natural immune cells, the start and recedion of natural immune, and the production of natural immune memory have become the leading hot spots in the international immunology field.
In this review, Cao Xuetao and Zhang Qi, associate professor of second military medical university, first outlined the new progress of oscic genetic regulation in recent years, including oxidation modification of DNA methylation such as 5-hydroxymed methylation, oscic transcription group composed of RNA modification such as m6A, and the advanced spatial structure of chromatin, which raised hot and difficult issues in the field of surface regulation.
, the paper summarizes the surface regulation model of natural immunity from four levels. First, focus on the differentiation and development of key natural immune cell types, such as macrophages, degeneration cells, and natural lymphocytes. By listing the representative research results in this field, the paper expounds how the tissue microenvironment signals can induce the maturity and polarization of natural immune cell characteristic differentiation through the hierarchy and mutual regulation of cell genealogy-specific transcription factors and osciential regulatory factors.
second, from the perspective of pathogen identification and its associated signaling pathogen transduction, infection signal-induced natural immune effect molecule expression on and off, the paper expounds how various surface regulatory molecules can control the chromosomal modification, RNA modification and non-classical protein modification levels, regulate the expression and activity of immune identification, signal transduction molecules, and the expression of natural immune effect molecules to maintain the precise balance of natural immune and inflammatory reactions.
Third, it expounds how pathogen composition or infection-induced cytokines at the time of infection can reshape the chromatin state of natural immune cells through the mutual regulation of osciential regulatory factors and signal transduction, induce natural immune tolerance or make them enter the "adaptive" state.
Fourth, the focus area hot spot - metabolic remodeling, described the infection signal induced or inhibited metabolic small molecules, or as an auxiliary active factor of the oscic modification enzyme class, directly or indirectly mediated gene-specific supersophic modification changes, as well as metabolic path and metastatic genetic cross-regulation, how to participate in the regulation of natural immune response.
Finally, in view of how to further study the differentiation, development process and infection and other environmental factors to induce natural immune cell ode metacontrolling group, in order to establish the characteristic functional state of natural immune cells, as well as the field of urgent problems to be solved, this paper systematically reveals the cell characteristics and gene specificity of the surface regulation process and its significance to health maintenance and disease prevention and control, and then put forward nine research directions of natural immunity and inflammatory ode regulation. (Source: Xin Yu, China Science Daily)
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