Capsaicin may be used to treat tumors

The newly published journal Nature Medicine reports an anti-tumor pathway in mice and human body, which includes capsaicin, a special fatty acid molecule secreted by neural progenitor cells (NPC) NPC is a kind of cell in children's brain, which can be used to deal with tumors and secrete substances to induce cancer cell death Rainer glass et al Identified the substances secreted as capsaicin, and elucidated the mechanism by which capsaicin protects the brain from tumors Capsaicin can send signals through TRPV1, which is highly expressed in malignant glioma, a brain cancer After capsaicin sends signals, it can activate a strengthened pathway in cancer cells to promote cancer cell death Using a synthetic capsaicin called arvanil to treat brain tumors in adult mice can show the tumor inhibitory effect of young NPC This study reveals a potentially powerful tumor suppressive effect using endogenous brain molecules, which depends on a large number of NPC, or has significance in the treatment of patients of different ages In addition, TRPV1, a capsaicin receptor, can be used as a candidate pathway for drug targeting in brain tumors.