Case Study: Multi-omics analysis reveals how gut microbes regulate body metabolism during bariatric surgery

At present, bariatric surgery is still an important surgical means to treat obesity and related complications

First, intestinal flora depletion can weaken the therapeutic effect of Roux-en-Y bariatric surgery on high-fat diet-induced obesity models

To investigate the specific role

Studies have shown that the gut microbiome plays an important role

(Figure 1)

Second, RYGB postoperative rat fecal bacteria transplantation can alleviate the HF-DIO rat phenotype

To further validate the important role played by gut microbes in bariatric surgery, the authors transplanted intestinal microbiota (FMT) from RYGB postoperative rats into HF-DIO rats

(Figure 2)

The authors further explore changes

(Figure 3)

Second, multi-omics techniques reveal that bariatric surgery or RYGB-FMT regulates taurine metabolism and the activity of intestinal bile acid receptors

The authors first used 16S rRNA technology to analyze the effects

(Figure 4)

Metabolites of microorganisms are key mediators

(Figure 5)

To better understand the changes in microbial metabolic function, the authors performed macroproteomic analysis

(Figure 6)

FXR and TGR5 play a key role in activating adipose tissue thermogenesis and improving metabolic capacity

The results of the current study prove that RYGB fecal bacteria transplantation improves metabolic health

In this study, it was found that changes in bile acids can induce systemic activation of FXR5, so RYGB-FMT did not induce increased thermogenesis and improvement

brief summary

In this study, through multi-omics, we elucidated the changes in intestinal microbiome before and after bariatric surgery and explored the mechanisms

References

Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity.

Please scan the QR code to read the original text

Plotted notation to help you measure

With the industry's powerful Q600 full quantitative metabolome, Q300 full quantitative metabolome, Q200 macro metabolome and microbiota-related 16S rDNA sequencing and metagenomic methods, Mater Spectrum can provide one-stop overall solutions for metabolomics, exclusive detection technology, comprehensive data reports and professional after-sales discussions, helping you to continuously innovate and break through