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Analytical Testing Encyclopedia News from August 9-13, 2021, Eastern Time, the first CASMS Symposium and Exhibition was grandly held in Gather.
Dr.
Report title: Going Beyond drivers in Renal Cell Carcinoma
Genomic change analysis showed that 3p deletion is an important marker of CCRCC
The report pointed out that CPTAC large-scale proteomics research lays the foundation for drug therapy.
Dr.
Report title: Valid-NEO: An Integrated System for Neoantigen Validation from Limited Clinical Samples
Neoantigens are newly formed antigens that have not been recognized by the immune system before.
However, there are three technical problems in neoantigen detection: 1.
The report introduced 2 representative studies using Valid-neo, and preliminary results have been achieved
Dr.
Report title: Misfolded Proteins in the Aged Brain
The report pointed out that specific brain regions showed obvious disease-specific vulnerability (neuronal contents are closely related to cell and function loss); multiple diseases often coexist in the brains of the elderly, which is for Alzheimer’s disease New treatment strategies bring hope; apolipoprotein E protein disease is the main dementia-related pathological biomarker for individuals with or without apolipoprotein Eε4 allele; in the brain of the elderly, there may be more than previously thought The pathogenic misfolded protein
Dr.
Report title: Proteogenomic Characterizations of Pancreatic Ductal Adenocarcinoma
The protein genomics characteristics of cancer refer to the link between genomic changes and the functional mechanism of cancer pathobiology.
The report introduced the use of orthogonal methods to determine the number of tumor cells in the study cohort, proteomics features revealed the functional impact of genomic changes and multiple subtypes, a list of proteins and glycoproteins used for early detection or therapeutic intervention, and phosphoproteome The science reveals hypothetical therapeutic targets downstream of KRAS, and the integration of multiple omics links endothelial cell remodeling and glycolysis with immune rejection
Dr.
Report title: High-Throughput Proteomics for Minute Amounts of Tissues
The proteome is very important for the diagnosis of diseases.
