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Researchers from the Suzhou Institute of Biomedical Engineering Technology (SIBEBT) of the Chinese Academy of Sciences have revealed the reasons for the inevitable occurrence of multidrug resistance in the process of tumor treatment through long-term research on the mechanism of tumor multidrug resistan.
Chemotherapy is one of the main ways of cancer treatment, but the occurrence of drug resistance often hinders chemotherapy, and eventually develops into multidrug resistance, making most drugs ineffecti.
Researchers have uncovered multiple resistance mechanisms, most notably the chemotherapeutic drug-induced adenosine triphosphate-binding cassette (ATP) transporter (AB.
Studies have shown that non-substrate nanoparticles can induce multidrug resistance by inducing oxidative damage, suggesting that multidrug resistance can be caused not only by substrates, but also by oxidative dama.
To confirm this conclusion, SIBEBT's Jian Yin and his team used a lung cancer cell line (A549) as a model to study the interaction of three chemicals (ethanol, hydrogen peroxide and doxorubicin) with the ABC transport.
Of these three chemicals, doxorubicin is a substrate for the ABC transporter and chemotherapeutic drugs, while ethanol and hydrogen peroxide are small-molecule compounds that have nothing to do with the function of the ABC transport.
"When these three substances enter cells, they cause significant oxidative stress within the cells," Yin sa.
Elevated oxidative stress induces the expression of transporters, which can reduce intracellular oxidative stress by releasing oxidized glutathio.
Their results show that non-substrate chemicals can also induce ABC transporter expression similar to chemotherapeutic drugs after inducing oxidative dama.
These conclusions confirm the relationship between multidrug resistance mechanisms and oxidative stre.
"Considering that peroxidative damage is a major source of the toxicity of current environmental pollutants, long-term exposure to environmental pollutants may not only lead to immediate toxicity, but may also further threaten human health by inducing multidrug resistance," said another study by the te.
Original title:
Oxidative stress-mediated up-regulation of ABC transporters in lung cancer cells
