CELL: After many years, finally found gram-negative bacteria new antibiotics!

Today, rising antibiotic resistance and the discovery of new antibiotics are decreasing, creating a global health crisisOf particular concern is the fact that no new antibiotic-type drug has been approved in recent decades for the treatment of Gram-negative pathogensrecently, researchers discovered a compound, SCH-7979797, that kills Gram-negative and Gram-positive bacteria at a low, undetectable low-drug frequency with a unique two-target mechanism (MoA)to characterize its MoA, researchers combined quantitative imaging, proteomics, genetics, metabolomics, and cell-based testingThe results showed that SCH-7979797 had two independent cell targets, namely folate metabolism and bacterial membrane integrity, and were superior to combination therapy in the killing of methicillin-resistant Staphylococcus aureus (MRSA)based on the molecular core of SCH-797977, the researchers also developed a derivative irresistin-16 that enhances its efficacy and shows efficacy against gonorrhea in models of vaginal infection in micethe discovery of this promising antibiotic suggests that binding multiple MoAs to a single chemical stent may be an unappreciated method that can be used to target challenging bacterial pathogens